PMID- 2905995
OWN - NLM
STAT- MEDLINE
DCOM- 19890314
LR  - 20171116
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 18
IP  - 12
DP  - 1988 Dec
TI  - Regulatory circuits in autoimmunity: recruitment of counter-regulatory CD8+ T 
      cells by encephalitogenic CD4+ T line cells.
PG  - 1993-9
AB  - In this study, pretreatment of Lewis rats with a syngeneic encephalitogenic T 
      cell line (S1) was found to be able to constantly induce resistance to the 
      subsequent induction of transferred experimental autoimmune encephalomyelitis 
      (tEAE). This treatment was capable of protecting recipient animals for at least 
      2-4 months. Here we show an enhanced suppressor T(anti-S1) cell activity, which 
      can be readily detected in the lymphoid organs of animals which recovered from 
      S1-induced tEAE, or from rats pretreated with attenuated (irradiated, fixative 
      treated or water-lysed) S1 cells. Anti-S1 cells, which uniformly express the CD8 
      phenotype, were selectively stimulated to grow and expand into lines by 
      confronting primed lymphoid cells with irradiated S1 cells in culture. The 
      proliferative response of anti-S1 cells was independent of myelin basic protein 
      and antigen-presenting cells, and the responses against unrelated 
      encephalitogenic T cell lines were minimal. It was also found that none of the 
      monoclonal antibodies tested (including CD8 and MHC class I antigen-specific 
      antibodies) was able to block S1/anti-S1 interactions. These cells are 
      functionally suppressive to the proliferation of S1 cells in vitro, are 
      specifically cytolytic directed against the EAE-inducing S1 cells and are able to 
      antagonize encephalitogenic capacity of S1 cells in vivo. In vivo elimination of 
      the CD8+ T subset from Lewis rats, using a combined treatment of thymectomy and 
      OX-8 antibody injection before the initial cell transfer, totally blocked the 
      induction of resistance. Our experiments document that induction of functionally 
      active suppressor T cells is responsible for the induced resistance observed in 
      tEAE.
FAU - Sun, D
AU  - Sun D
AD  - Max-Planck-Society, Clinical Research Unit for Multiple Sclerosis, Wurzburg, FRG.
FAU - Ben-Nun, A
AU  - Ben-Nun A
FAU - Wekerle, H
AU  - Wekerle H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (CD8 Antigens)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal
MH  - Antigens, Differentiation, T-Lymphocyte/analysis
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - CD8 Antigens
MH  - Clone Cells/immunology
MH  - Encephalomyelitis, Autoimmune, Experimental/*immunology
MH  - In Vitro Techniques
MH  - Lymphocyte Activation
MH  - Rats
MH  - Rats, Inbred Lew
MH  - T-Lymphocytes, Helper-Inducer/*immunology
MH  - T-Lymphocytes, Regulatory/*immunology
EDAT- 1988/12/01 00:00
MHDA- 1988/12/01 00:01
CRDT- 1988/12/01 00:00
PHST- 1988/12/01 00:00 [pubmed]
PHST- 1988/12/01 00:01 [medline]
PHST- 1988/12/01 00:00 [entrez]
AID - 10.1002/eji.1830181219 [doi]
PST - ppublish
SO  - Eur J Immunol. 1988 Dec;18(12):1993-9. doi: 10.1002/eji.1830181219.