PMID- 2906000
OWN - NLM
STAT- MEDLINE
DCOM- 19890316
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 152
IP  - 3
DP  - 1988 Aug 2
TI  - Differences between rats and mice in MDMA (methylenedioxymethylamphetamine) 
      neurotoxicity.
PG  - 227-34
AB  - In both rats and mice a single large dose of methylenedioxymethylamphetamine 
      (MDMA; 25 mg/kg i.p.) caused a fall 3 h after injection in the content of 
      5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in cortex, a 
      fall in noradrenaline in hippocampus and cerebellum, and a rise in dopamine (DA) 
      but fall in dihydroxyphenylacetic acid (DOPAC) in striatum. These effects were 
      transient, levels being essentially back to normal by 24 h after injection. 
      Repeated large doses (3 x 25 mg/kg in 24 h) of MDMA caused a large long-lasting 
      fall in the content of 5-HT and 5-HIAA in cortex in rats but had only a slight 
      effect in mice. Increasing the dose to 3 x 50 mg/kg in mice produced a large 
      long-lasting fall in striatal DA. The analogue 
      MDEA(3,4-methylenedioxyethylamphetamine) caused a similar slight fall in 5-HT but 
      in contrast to MDMA caused a slight rise in DA content in mice. The nature and 
      degree of neurotoxicity with methylenedioxyamphetamines appears to be drug and 
      species-specific.
FAU - Logan, B J
AU  - Logan BJ
AD  - Department of Pharmacology, University of Otago Medical School, Dunedin, New 
      Zealand.
FAU - Laverty, R
AU  - Laverty R
FAU - Sanderson, W D
AU  - Sanderson WD
FAU - Yee, Y B
AU  - Yee YB
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Amphetamines)
RN  - 0 (Biogenic Monoamines)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 534-82-7 (Methoxyhydroxyphenylglycol)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - ML1I4KK67B (3,4-methylenedioxyethamphetamine)
RN  - UEH9K539KJ (3,4-dihydroxyphenylglycol)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/pharmacology/*toxicity
MH  - Amphetamines/*toxicity
MH  - Animals
MH  - Biogenic Monoamines/metabolism
MH  - Dopamine/metabolism
MH  - Male
MH  - Methoxyhydroxyphenylglycol/analogs & derivatives/metabolism
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Nervous System Diseases/*chemically induced/metabolism
MH  - Norepinephrine/metabolism
MH  - Rats
MH  - Species Specificity
EDAT- 1988/08/02 00:00
MHDA- 1988/08/02 00:01
CRDT- 1988/08/02 00:00
PHST- 1988/08/02 00:00 [pubmed]
PHST- 1988/08/02 00:01 [medline]
PHST- 1988/08/02 00:00 [entrez]
AID - 0014-2999(88)90717-0 [pii]
AID - 10.1016/0014-2999(88)90717-0 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1988 Aug 2;152(3):227-34. doi: 10.1016/0014-2999(88)90717-0.