PMID- 29061223
OWN - NLM
STAT- MEDLINE
DCOM- 20180611
LR  - 20201019
IS  - 1488-2353 (Electronic)
IS  - 0147-958X (Linking)
VI  - 40
IP  - 5
DP  - 2017 Oct 19
TI  - Association between donor and recipient Interleukin-18 gene polymorphisms and the 
      risk of infection after liver transplantation.
PG  - E176-E187
LID - 10.25011/cim.v40i5.28623 [doi]
AB  - PURPOSE: The purpose of this study was to retrospectively evaluate the 
      association between Interleukin-18 (IL-18) gene polymorphisms of the donor and 
      recipient in liver transplant patients with bacterial infections. METHODS: Five 
      single nucleotide polymorphisms (SNPs) (rs7106524, rs5744247, rs1946518, rs549908 
      and rs187238) of the IL-18 gene from the donors were genotyped and their 
      association with post-operative bacterial infections was evaluated in liver 
      transplant patients (N=113). A second independent group of liver transplant 
      patients from a different organ transplant centre was also recruited for 
      validation purposes (N=44). RESULTS: IL-18 mRNA mean expression levels and 
      protein levels were significantly lower in liver transplant patients with 
      bacterial infections. For the donor SNP rs1946518, more recipients carried the A 
      allele in the bacterial-infected group than the uninfected group (61.4% vs 39.7%; 
      P </=0.002). The mean IL-18 mRNA expression and protein levels were significantly 
      lower in the transplanted livers of recipients carrying the rs1946518 AA genotype 
      compared with those from recipients with CC genotype (3.64, 3.33 vs. 2.75, 
      P</=0.048). The A allele of rs1946518 also resulted in lower luciferase activity 
      than the C allele in a reporter assay. The area under ROC curve indicated that 
      the rs1946518 SNP genotype in the donor liver predicted an increased risk of 
      bacterial infection after liver transplantation (AUROC>0.82). CONCLUSIONS: These 
      findings indicate that the IL-18 rs1946518 SNP in the donor liver is a risk 
      factor for developing bacterial infection after liver transplantation.
FAU - Shi, Bao-Jie
AU  - Shi BJ
AD  - Department of General Surgery, Shanghai First People Hospital, Medical School of 
      Shanghai Jiaotong University. email@email.com.
FAU - Yu, Xiao-Yu
AU  - Yu XY
FAU - Li, Hao
AU  - Li H
FAU - Xing, Tong-Hai
AU  - Xing TH
FAU - Fan, Jun-Wei
AU  - Fan JW
FAU - Wang, Pei-Wen
AU  - Wang PW
FAU - Peng, Zhi-Hai
AU  - Peng ZH
FAU - Zhong, Lin
AU  - Zhong L
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20171019
PL  - Canada
TA  - Clin Invest Med
JT  - Clinical and investigative medicine. Medecine clinique et experimentale
JID - 7804071
RN  - 0 (IL18 protein, human)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Bacterial Infections/etiology/*genetics
MH  - Female
MH  - Gene Expression Regulation
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Liver Transplantation/*adverse effects
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Postoperative Complications/*genetics
MH  - *Tissue Donors
EDAT- 2017/10/25 06:00
MHDA- 2018/06/12 06:00
CRDT- 2017/10/25 06:00
PHST- 2017/10/19 00:00 [received]
PHST- 2017/10/25 06:00 [entrez]
PHST- 2017/10/25 06:00 [pubmed]
PHST- 2018/06/12 06:00 [medline]
AID - 10.25011/cim.v40i5.28623 [doi]
PST - epublish
SO  - Clin Invest Med. 2017 Oct 19;40(5):E176-E187. doi: 10.25011/cim.v40i5.28623.