PMID- 29061333
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1523-1755 (Electronic)
IS  - 0085-2538 (Linking)
VI  - 93
IP  - 2
DP  - 2018 Feb
TI  - Novel aspects of epitope matching and practical application in kidney 
      transplantation.
PG  - 314-324
LID - S0085-2538(17)30604-X [pii]
LID - 10.1016/j.kint.2017.08.008 [doi]
AB  - This review describes the recent developments in the applicability and clinical 
      significance of epitope matching in kidney transplantation. As incremental human 
      leukocyte antigen (HLA) mismatches are associated with increased risk of 
      rejection and allograft loss, HLA-matching remains one of the standard 
      immunological triage tests to determine transplant suitability. Advancements in 
      tissue-typing techniques have led to innovative concepts of HLA-matching at the 
      epitope level. Epitopes are configurations of polymorphic amino acid residues 
      that are recognized by B cells, and antibodies reactive with these epitopes lead 
      to rejection and/or premature allograft loss. Even though there is substantial 
      advancement in the characterization and understanding of epitopes, evidence 
      supporting the added clinical benefit of epitope matching over traditional 
      antigen matching and the ability to identify clinically relevant immunogenic 
      epitopes remains poorly defined. We present an overview of the evidence 
      surrounding the immunogenicity of mismatched donor epitopes and the applicability 
      of HLA epitope matching in kidney transplantation. A better understanding of the 
      immunogenicity and structural characteristics of HLA epitopes will guide 
      clinicians to integrate epitope matching as an important parameter for donor 
      selection in kidney transplantation.
CI  - Copyright (c) 2017 International Society of Nephrology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Lim, Wai H
AU  - Lim WH
AD  - Department of Renal Medicine, Sir Charles Gairdner Hospital, Perth, Western 
      Australia, Australia; School of Medicine and Pharmacology, The University of 
      Western Australia, Perth, Western Australia, Australia. Electronic address: 
      wai.lim@health.wa.gov.au.
FAU - Wong, Germaine
AU  - Wong G
AD  - Sydney School of Public Health, The University of Sydney, Sydney, New South 
      Wales, Australia; Centre for Kidney Research, The Children's Hospital at Westmead 
      and the Centre for Transplant and Renal Research, Westmead Hospital, Sydney, New 
      South Wales, Australia.
FAU - Heidt, Sebastiaan
AU  - Heidt S
AD  - Eurotransplant Reference Laboratory, Department Immunohematology and Blood 
      Transfusion, Leiden University Medical Centre, Leiden, The Netherlands.
FAU - Claas, Frans H J
AU  - Claas FHJ
AD  - Eurotransplant Reference Laboratory, Department Immunohematology and Blood 
      Transfusion, Leiden University Medical Centre, Leiden, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20171020
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - *Donor Selection
MH  - *Epitope Mapping
MH  - Graft Rejection/immunology/*prevention & control
MH  - Graft Survival
MH  - HLA Antigens/*immunology
MH  - *Histocompatibility
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Isoantibodies/*immunology
MH  - Kidney Transplantation/adverse effects/*methods
MH  - Predictive Value of Tests
MH  - Risk Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - acute rejection
OT  - chronic kidney disease
OT  - epitope
OT  - histocompatibility
OT  - kidney transplantation
OT  - tissue typin
EDAT- 2017/10/25 06:00
MHDA- 2018/12/12 06:00
CRDT- 2017/10/25 06:00
PHST- 2017/05/26 00:00 [received]
PHST- 2017/07/30 00:00 [revised]
PHST- 2017/08/03 00:00 [accepted]
PHST- 2017/10/25 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2017/10/25 06:00 [entrez]
AID - S0085-2538(17)30604-X [pii]
AID - 10.1016/j.kint.2017.08.008 [doi]
PST - ppublish
SO  - Kidney Int. 2018 Feb;93(2):314-324. doi: 10.1016/j.kint.2017.08.008. Epub 2017 
      Oct 20.