PMID- 29062839
OWN - NLM
STAT- MEDLINE
DCOM- 20180618
LR  - 20190723
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2017
DP  - 2017
TI  - Antidiabetic Effect of Brain-Derived Neurotrophic Factor and Its Association with 
      Inflammation in Type 2 Diabetes Mellitus.
PG  - 2823671
LID - 10.1155/2017/2823671 [doi]
LID - 2823671
AB  - Brain-derived neurotrophic factor (BDNF) is a neurotrophin, which plays an 
      important role in the central nervous system, and systemic or peripheral 
      inflammatory conditions, such as acute coronary syndrome and type 2 diabetes 
      mellitus (T2DM). BDNF is also expressed in several nonneuronal tissues, and 
      platelets are the major source of peripheral BDNF. Here, we reviewed the 
      potential role of BDNF in platelet reactivity in T2DM and its association with 
      selected inflammatory and platelet activation mediators. Besides that, we focused 
      on adipocytokines such as leptin, resistin, and adiponectin which are considered 
      to take part in inflammation and both lipid and glucose metabolism in diabetic 
      patients as previous studies showed the relation between adipocytokines and BDNF. 
      We also reviewed the evidences of the antidiabetic effect of BDNF and the 
      association with circulating inflammatory cytokines in T2DM.
FAU - Eyileten, Ceren
AU  - Eyileten C
AUID- ORCID: 0000-0002-3324-9625
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Center for Preclinical Research and Technology CEPT, Warsaw, Poland.
FAU - Kaplon-Cieslicka, Agnieszka
AU  - Kaplon-Cieslicka A
AD  - Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
FAU - Mirowska-Guzel, Dagmara
AU  - Mirowska-Guzel D
AUID- ORCID: 0000-0001-6294-3256
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Center for Preclinical Research and Technology CEPT, Warsaw, Poland.
FAU - Malek, Lukasz
AU  - Malek L
AD  - Faculty of Rehabilitation, University of Physical Education, Warsaw, Poland.
FAU - Postula, Marek
AU  - Postula M
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Center for Preclinical Research and Technology CEPT, Warsaw, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170914
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Adipokines)
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Inflammation Mediators)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Adipokines/blood
MH  - Animals
MH  - Blood Glucose/drug effects/metabolism
MH  - Blood Platelets/drug effects/metabolism
MH  - Brain/*drug effects/metabolism/physiopathology
MH  - Brain-Derived Neurotrophic Factor/adverse effects/blood/*therapeutic use
MH  - Cytokines/blood
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy/epidemiology/physiopathology
MH  - Humans
MH  - Hypoglycemic Agents/adverse effects/*therapeutic use
MH  - Inflammation/*blood/epidemiology/physiopathology
MH  - Inflammation Mediators/blood
MH  - Platelet Activation/drug effects
MH  - Receptor, trkB/agonists/metabolism
MH  - Signal Transduction/drug effects
MH  - Treatment Outcome
PMC - PMC5618763
EDAT- 2017/10/25 06:00
MHDA- 2018/06/19 06:00
PMCR- 2017/09/14
CRDT- 2017/10/25 06:00
PHST- 2017/04/24 00:00 [received]
PHST- 2017/07/12 00:00 [revised]
PHST- 2017/08/22 00:00 [accepted]
PHST- 2017/10/25 06:00 [entrez]
PHST- 2017/10/25 06:00 [pubmed]
PHST- 2018/06/19 06:00 [medline]
PHST- 2017/09/14 00:00 [pmc-release]
AID - 10.1155/2017/2823671 [doi]
PST - ppublish
SO  - J Diabetes Res. 2017;2017:2823671. doi: 10.1155/2017/2823671. Epub 2017 Sep 14.