PMID- 29063029
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2095-882X (Print)
IS  - 2589-0514 (Electronic)
IS  - 2095-882X (Linking)
VI  - 2
IP  - 2
DP  - 2016 Jun
TI  - Stem cell transplantation dose in patients with acute myocardial infarction: A 
      meta-analysis.
PG  - 92-101
LID - 10.1016/j.cdtm.2016.09.006 [doi]
AB  - OBJECTIVE: To evaluate whether stem cell transplantation improves global left 
      ventricular ejection fraction (LVEF) in patients with acute myocardial infarction 
      (AMI), and to determine the appropriate stem cell therapy dose as well as the 
      effective period after stem cell transplantation for therapy. METHODS: A 
      systematic literature search included Pubmed, MEDLINE, China National Knowledge 
      Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), and Cochrane 
      Evidence-Based Medicine databases. The retrieval time limit ranged from January 
      1990 to June 2016. We also obtained full texts through manual retrieval, 
      interlibrary loan and document delivery service, or by contacting the authors 
      directly. According to our inclusion and exclusion criteria, data were extracted 
      independently by two evaluators. In case of disagreement, a joint discussion 
      occurred and a third researcher was utilized. Data were analyzed quantitatively 
      using Revman 5.2. Summary results are presented as the weighted mean difference 
      (WMD) with 95% confidence intervals (CIs). We collected individual trial data and 
      conducted a meta-analysis to compare changes in global left ventricular ejection 
      fraction (DeltaLVEF) after stem cell therapy. In this study, four subgroups were 
      based on stem cell dose (</=1 x 10(7) cells, </=1 x 10(8) cells, </=1 x 10(9) cells, 
      and </=1 x 10(10) cells) and three subgroups were based on follow-up time (<6 
      months, 6-12 months, and >/=12 months). RESULTS: Thirty-four studies, which 
      included 40 randomized controlled trials, were included in this meta-analysis, 
      and 1927 patients were evaluated. Changes in global LVEF were significantly 
      higher in the stem cell transplantation group than in the control group (95% CI: 
      2.35-4.26%, P < 0.01). We found no significant differences in DeltaLVEF between the 
      bone marrow stem cells (BMCs) group and control group when the dose of BMCs was 
      </=1 x 10(7) [DeltaLVEF 95% CI: 0.12-3.96%, P = 0.04]. The DeltaLVEF in the BMCs groups was 
      significantly higher than in the control groups when the dose of BMCs was 
      </=1 x 10(8) [DeltaLVEF 95% CI: 0.95-4.25%, P = 0.002] and </=1 x 10(9) [DeltaLVEF 95% 
      CI: 2.31-4.20%, P < 0.01]. In addition, when the dose of BMCs was between 10(9) 
      and 10(10) cells, we did not observe any significant differences [DeltaLVEF 95% CI: 
      -0.99-11.82%, P = 0.10]. Our data suggest stem cell therapy improves cardiac 
      function in AMI patients when treated with an appropriate dose of BMCs. 
      CONCLUSION: Stem cell transplantation after AMI could improve global LVEF. Stem 
      cells may be effectively administered to patients with AMI doses between 10(8) 
      and 10(9) cells.
FAU - Xu, Jia-Ying
AU  - Xu JY
AD  - The Department of Cardiology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, Liaoning 116000, China.
FAU - Cai, Wen-Yuan
AU  - Cai WY
AD  - The Department of Cardiology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, Liaoning 116000, China.
FAU - Tian, Ming
AU  - Tian M
AD  - The Department of Cardiology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, Liaoning 116000, China.
FAU - Liu, Dai
AU  - Liu D
AD  - The Department of Cardiology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, Liaoning 116000, China.
FAU - Huang, Rong-Chong
AU  - Huang RC
AD  - The Department of Cardiology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, Liaoning 116000, China.
LA  - eng
PT  - Journal Article
DEP - 20161109
PL  - United States
TA  - Chronic Dis Transl Med
JT  - Chronic diseases and translational medicine
JID - 101679934
PMC - PMC5643746
OTO - NOTNLM
OT  - Acute myocardial infarction
OT  - Cell dosage
OT  - Left ventricular ejection fraction
OT  - Stem cell
EDAT- 2017/10/25 06:00
MHDA- 2017/10/25 06:01
PMCR- 2016/11/09
CRDT- 2017/10/25 06:00
PHST- 2016/08/31 00:00 [received]
PHST- 2017/10/25 06:00 [entrez]
PHST- 2017/10/25 06:00 [pubmed]
PHST- 2017/10/25 06:01 [medline]
PHST- 2016/11/09 00:00 [pmc-release]
AID - S2095-882X(16)30074-3 [pii]
AID - 10.1016/j.cdtm.2016.09.006 [doi]
PST - epublish
SO  - Chronic Dis Transl Med. 2016 Nov 9;2(2):92-101. doi: 10.1016/j.cdtm.2016.09.006. 
      eCollection 2016 Jun.