PMID- 29063254
OWN - NLM
STAT- MEDLINE
DCOM- 20180802
LR  - 20200330
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 28
IP  - 4
DP  - 2018 Apr
TI  - Dual-layer DECT for multiphasic hepatic CT with 50 percent iodine load: a 
      matched-pair comparison with a 120 kVp protocol.
PG  - 1719-1730
LID - 10.1007/s00330-017-5114-3 [doi]
AB  - OBJECTIVES: To evaluate the image quality and lesion conspicuity of 
      virtual-monochromatic-imaging (VMI) with dual-layer DECT (DL-DECT) for 
      reduced-iodine-load multiphasic-hepatic CT. METHODS: Forty-five adults with renal 
      dysfunction who had undergone hepatic DL-DECT with 300-mgI/kg were included. VMI 
      (40-70-keV, DL-DECT-VMI) was generated at each enhancement phase. As controls, 45 
      matched patients undergoing standard 120-kVp protocol (120-kVp, 600-mgI/kg, and 
      iterative reconstruction) were included. We compared the size-specific dose 
      estimate (SSDE), image noise, CT attenuation, and contrast-to-noise ratio (CNR) 
      between protocols. Two radiologists scored the image quality and lesion 
      conspicuity. RESULTS: SSDE was significantly lower in DL-DECT group (p < 0.01). 
      Image noise of DL-DECT-VMI was almost constant at each keV (differences of </=15%) 
      and equivalent to or lower than of 120-kVp. As the energy decreased, CT 
      attenuation and CNR gradually increased; the values of 55-60 keV images were 
      almost equivalent to those of standard 120-kVp. The highest scores for overall 
      quality and lesion conspicuity were assigned at 40-keV followed by 45 to 55-keV, 
      all of which were similar to or better than of 120-kVp. CONCLUSIONS: For 
      multiphasic-hepatic CT with 50% iodine-load, DL-DECT-VMI at 40- to 55-keV 
      provides equivalent or better image quality and lesion conspicuity without 
      increasing radiation dose compared with standard 120-kVp protocol. KEY POINTS: * 
      40-55-keV yields optimal image quality for half-iodine-load multiphasic-hepatic 
      CT with DL-DECT. * DL-DECT protocol decreases radiation exposure compared with 
      120-kVp scans with iterative reconstruction. * 40-keV images maximise conspicuity 
      of hepatocellular carcinoma especially at hepatic-arterial phase.
FAU - Nagayama, Yasunori
AU  - Nagayama Y
AUID- ORCID: 0000-0003-3280-7346
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto 
      University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan. 
      y.nagayama1980@gmail.com.
FAU - Nakaura, Takeshi
AU  - Nakaura T
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto 
      University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
FAU - Oda, Seitaro
AU  - Oda S
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto 
      University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
FAU - Utsunomiya, Daisuke
AU  - Utsunomiya D
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto 
      University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
FAU - Funama, Yoshinori
AU  - Funama Y
AD  - Department of Medical Physics, Faculty of Life Sciences, Kumamoto University, 
      4-24-1 Kuhonji, Chuo-ku, Kumamoto, 862-0976, Japan.
FAU - Iyama, Yuji
AU  - Iyama Y
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto 
      University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
FAU - Taguchi, Narumi
AU  - Taguchi N
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto 
      University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
FAU - Namimoto, Tomohiro
AU  - Namimoto T
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto 
      University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
FAU - Yuki, Hideaki
AU  - Yuki H
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto 
      University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
FAU - Kidoh, Masafumi
AU  - Kidoh M
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto 
      University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
FAU - Hirata, Kenichiro
AU  - Hirata K
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto 
      University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
FAU - Nakagawa, Masataka
AU  - Nakagawa M
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto 
      University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
FAU - Yamashita, Yasuyuki
AU  - Yamashita Y
AD  - Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto 
      University, 1-1-1, Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
LA  - eng
PT  - Journal Article
DEP - 20171023
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - 0 (Contrast Media)
RN  - 9679TC07X4 (Iodine)
SB  - IM
MH  - Aged
MH  - Carcinoma, Hepatocellular/diagnostic imaging
MH  - Contrast Media
MH  - Female
MH  - Humans
MH  - Iodine
MH  - Liver Diseases/*diagnostic imaging
MH  - Liver Neoplasms/diagnostic imaging
MH  - Male
MH  - Multidetector Computed Tomography/*methods
MH  - Radiation Exposure
MH  - Radiographic Image Interpretation, Computer-Assisted/methods
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Hepatocellular carcinoma
OT  - Image enhancement
OT  - Iodine
OT  - Liver diseases
OT  - Multidetector computed tomography
EDAT- 2017/10/25 06:00
MHDA- 2018/08/03 06:00
CRDT- 2017/10/25 06:00
PHST- 2017/07/28 00:00 [received]
PHST- 2017/10/02 00:00 [accepted]
PHST- 2017/09/15 00:00 [revised]
PHST- 2017/10/25 06:00 [pubmed]
PHST- 2018/08/03 06:00 [medline]
PHST- 2017/10/25 06:00 [entrez]
AID - 10.1007/s00330-017-5114-3 [pii]
AID - 10.1007/s00330-017-5114-3 [doi]
PST - ppublish
SO  - Eur Radiol. 2018 Apr;28(4):1719-1730. doi: 10.1007/s00330-017-5114-3. Epub 2017 
      Oct 23.