PMID- 29063347
OWN - NLM
STAT- MEDLINE
DCOM- 20180816
LR  - 20181113
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 43
IP  - 2
DP  - 2018 Feb
TI  - Nrf2 Signaling Pathway Mediates the Antioxidative Effects of Taurine Against 
      Corticosterone-Induced Cell Death in HUMAN SK-N-SH Cells.
PG  - 276-286
LID - 10.1007/s11064-017-2419-1 [doi]
AB  - Substantial evidence has shown that elevated circulating corticosteroids or 
      chronic stress contributes to neuronal cell death, cognitive and mental 
      disorders. However, the underlying mechanism is still unclear. Taurine is 
      considered to protect neuronal cells from apoptotic cell death in 
      neurodegenerative diseases and neuropsychiatric disorders. In the present study, 
      the protective effects of taurine against corticosterone (CORT)-induced oxidative 
      damage in SK-N-SH neuronal cells were investigated. The results showed that CORT 
      significantly induced cell death, which was blocked by pretreatment with taurine. 
      Similarly, pretreatment with taurine suppressed CORT-induced apoptotic cell death 
      decreasing the levels of intracellular reactive oxygen species and improving 
      mitochondrial function. Pretreatment with taurine increased the expression of 
      phosphorylated extracellular regulated protein kinases (ERK) as well as the 
      nuclear translocation of nuclear factor (erythroid 2-derived)-like 2 (Nrf2) in 
      the CORT rich environment. Furthermore, administration of the ERK inhibitor U0126 
      or transient (siRNA) silencing of Nrf2 blocked the protective effects of taurine 
      on cell viability and expression levels of Nrf2 and heme oxygenase-1 (HO-1) in 
      the CORT model of neuronal damage. These results suggest that the Nrf2 signaling 
      pathway may play a role in the protection mechanism of taurine against 
      CORT-induced neuronal oxidative damage.
FAU - Sun, Qinru
AU  - Sun Q
AD  - Institute of Forensic Medicine, Xi'an Jiaotong University Health Science Center, 
      Xi'an, 710061, Shaanxi, People's Republic of China.
FAU - Jia, Ning
AU  - Jia N
AUID- ORCID: 0000-0001-6434-170X
AD  - Department of Human Anatomy, Histology and Embryology, School of Basic Medical 
      Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, 
      Shaanxi, People's Republic of China. jianing@mail.xjtu.edu.cn.
FAU - Yang, Jie
AU  - Yang J
AD  - Department of Human Anatomy, Histology and Embryology, School of Basic Medical 
      Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, 
      Shaanxi, People's Republic of China.
FAU - Chen, Guomin
AU  - Chen G
AD  - Department of Human Anatomy, Histology and Embryology, School of Basic Medical 
      Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, 
      Shaanxi, People's Republic of China.
LA  - eng
GR  - 81500927/National Youth Foundation of China/
GR  - 31200843/National Natural Science Foundation of China/
GR  - No.2017JM8017/Natural Science Basic Research Plan in Shaanxi Province of China/
GR  - 2016JM8041/Natural Science Basic Research Plan in Shaanxi Province of China/
GR  - xjj2015077/Fundamental Research Funds for the Central Universities/
PT  - Journal Article
DEP - 20171023
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Antioxidants)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Protective Agents)
RN  - 0 (Reactive Oxygen Species)
RN  - 1EQV5MLY3D (Taurine)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Antioxidants/*pharmacology
MH  - Apoptosis/drug effects
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects
MH  - Corticosterone/metabolism/pharmacology
MH  - Humans
MH  - NF-E2-Related Factor 2/*metabolism
MH  - Protective Agents/pharmacology
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Reactive Oxygen Species/metabolism
MH  - Signal Transduction/*drug effects
MH  - Taurine/*pharmacology
OTO - NOTNLM
OT  - Corticosterone
OT  - Mitochondria
OT  - Nrf2
OT  - Reactive oxygen species
OT  - Taurine
EDAT- 2017/10/25 06:00
MHDA- 2018/08/17 06:00
CRDT- 2017/10/25 06:00
PHST- 2017/06/08 00:00 [received]
PHST- 2017/10/09 00:00 [accepted]
PHST- 2017/10/06 00:00 [revised]
PHST- 2017/10/25 06:00 [pubmed]
PHST- 2018/08/17 06:00 [medline]
PHST- 2017/10/25 06:00 [entrez]
AID - 10.1007/s11064-017-2419-1 [pii]
AID - 10.1007/s11064-017-2419-1 [doi]
PST - ppublish
SO  - Neurochem Res. 2018 Feb;43(2):276-286. doi: 10.1007/s11064-017-2419-1. Epub 2017 
      Oct 23.