PMID- 29064023
OWN - NLM
STAT- MEDLINE
DCOM- 20180709
LR  - 20181113
IS  - 1558-822X (Electronic)
IS  - 1558-8211 (Linking)
VI  - 12
IP  - 6
DP  - 2017 Dec
TI  - Diagnostic and Prognostic Utility of Fluorescence In situ Hybridization (FISH) 
      Analysis in Acute Myeloid Leukemia.
PG  - 568-573
LID - 10.1007/s11899-017-0426-6 [doi]
AB  - PURPOSE OF REVIEW: Acute myeloid leukemia (AML) is a hematologic neoplasia 
      consisting of incompletely differentiated hematopoietic cells of the myeloid 
      lineage that proliferate in the bone marrow, blood, and/or other tissues. 
      Clinical implementation of fluorescence in situ hybridization (FISH) in 
      cytogenetic laboratories allows for high-resolution analysis of recurrent 
      structural chromosomal rearrangements specific to AML, especially in AML with 
      normal karyotypes, which comprises approximately 33-50% of AML-positive 
      specimens. Here, we review the use of several FISH probe strategies in the 
      diagnosis of AML. We also review the standards and guidelines currently in place 
      for use by clinical cytogenetic laboratories in the evaluation of AML. RECENT 
      FINDINGS: Updated standards and guidelines from the WHO, ACMG, and NCCN have 
      further defined clinically significant, recurring cytogenetic anomalies in AML 
      that are detectable by FISH. FISH continues to be a powerful technique in the 
      diagnosis of AML, with higher resolution than conventional cytogenetic analysis, 
      rapid turnaround time, and a considerable diagnostic and prognostic utility.
FAU - Gonzales, Patrick R
AU  - Gonzales PR
AD  - Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, 
      35294, USA.
FAU - Mikhail, Fady M
AU  - Mikhail FM
AD  - Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, 
      35294, USA. fmikhail@uab.edu.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Hematol Malig Rep
JT  - Current hematologic malignancy reports
JID - 101262565
SB  - IM
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Leukemia, Myeloid, Acute/*diagnostic imaging/pathology
MH  - Male
MH  - Prognosis
OTO - NOTNLM
OT  - AML
OT  - Diagnosis
OT  - FISH
OT  - Gene fusion
OT  - Probe
OT  - Prognosis
EDAT- 2017/10/25 06:00
MHDA- 2018/07/10 06:00
CRDT- 2017/10/25 06:00
PHST- 2017/10/25 06:00 [pubmed]
PHST- 2018/07/10 06:00 [medline]
PHST- 2017/10/25 06:00 [entrez]
AID - 10.1007/s11899-017-0426-6 [pii]
AID - 10.1007/s11899-017-0426-6 [doi]
PST - ppublish
SO  - Curr Hematol Malig Rep. 2017 Dec;12(6):568-573. doi: 10.1007/s11899-017-0426-6.