PMID- 29065194
OWN - NLM
STAT- MEDLINE
DCOM- 20190725
LR  - 20200930
IS  - 1469-994X (Electronic)
IS  - 1462-2203 (Linking)
VI  - 20
IP  - 4
DP  - 2018 Mar 6
TI  - Nicotine-Induced Neuroprotection against Cognitive Dysfunction after Partial 
      Hepatectomy Involves Activation of BDNF/TrkB Signaling Pathway and Inhibition of 
      NF-kappaB Signaling Pathway in Aged Rats.
PG  - 515-522
LID - 10.1093/ntr/ntx157 [doi]
AB  - INTRODUCTION: The main purpose of this study was to investigate the effects and 
      possible mechanisms of nicotine pre-treatment on postoperative cognitive 
      dysfunction (POCD) in aged rats. METHODS: Nicotine (0.5 mg/kg) was given i.p. 
      immediately after anesthesia induction. After the Morris water maze test was used 
      to evaluate the rats' spatial learning and memory, serum and hippocampal tissues 
      were harvested 1 and 3 days after intervention. Inflammatory cytokines in the 
      serum were evaluated by Enzyme-linked Immunosorbent Assay (ELISA). Brain-derived 
      neurotrophic factor (BDNF), p-TrkB, neuroinflammation cytokines, NF-kappaB p65, and 
      cleaved caspase-3 were measured by western blotting; neuronal apoptosis in the 
      hippocampal CA1 region was also evaluated by TUNEL staining. RESULTS: We found 
      that nicotine markedly attenuated the POCD and reduced the elevated levels of 
      inflammatory cytokines in the serum, including IL-1beta and high mobility group 
      box-1 (HMGB1), on postoperative day 1. Additionally, nicotine suppressed the 
      surgery-induced release of IL-1beta, TNF-a, HMGB1, and NF-kappaB p65 in the hippocampus 
      on postoperative day 1 and day 3. In addition, operated rats displayed lower BDNF 
      and p-TrkB in the hippocampus on postoperative day 1, returning to baseline by 
      postoperative day 3. However, nicotine pre-treatment clearly reversed the 
      surgical stress-induced decrease in both BDNF and p-TrkB expression in the 
      hippocampus. Furthermore, nicotine pre-treatment significantly alleviated the 
      surgery-induced increase in the neuronal apoptosis in the hippocampus on 
      postoperative day 1 and day 3. CONCLUSIONS: Our results showed that 
      nicotine-induced neuroprotection against POCD may involve activation of the 
      BDNF/TrkB signaling pathway and inhibition of the NF-kappaB signaling pathway. 
      IMPLICATIONS: Nicotine has long been considered a potent therapeutic agent for 
      neuroprotection. This study reported the positive effect of nicotine treatment on 
      cognitive dysfunction after partial hepatectomy in aged rats. Furthermore, the 
      underlying mechanism may involve activation of the BDNF/TrkB signaling pathway 
      and inhibition of the NF-kappaB signaling pathway in the hippocampus.
FAU - Wei, Penghui
AU  - Wei P
AD  - Department of Anesthesiology, Qilu Hospital of Shandong University (Qingdao), 
      Qingdao, P.R. China.
FAU - Zheng, Qiang
AU  - Zheng Q
AD  - Department of Anesthesiology, Qilu Hospital of Shandong University (Qingdao), 
      Qingdao, P.R. China.
FAU - Liu, Hui
AU  - Liu H
AD  - Department of Anesthesiology, Qilu Hospital of Shandong University (Qingdao), 
      Qingdao, P.R. China.
AD  - Department of Anesthesiology, Shandong Univeristy School of Medicine, Jinan, 
      Shandong, P.R. China.
FAU - Wan, Tiantian
AU  - Wan T
AD  - Department of Anesthesiology, Qilu Hospital of Shandong University (Qingdao), 
      Qingdao, P.R. China.
AD  - Department of Anesthesiology, Shandong Univeristy School of Medicine, Jinan, 
      Shandong, P.R. China.
FAU - Zhou, Jinfeng
AU  - Zhou J
AD  - Department of Anesthesiology, Qilu Hospital of Shandong University (Qingdao), 
      Qingdao, P.R. China.
FAU - Li, Dong
AU  - Li D
AD  - Department of Cryomedicine, Qilu Hospital, Shandong University, Jinan, Shandong, 
      P.R. China.
FAU - Zhou, Haipeng
AU  - Zhou H
AD  - Department of Anesthesiology, Qilu Hospital of Shandong University (Qingdao), 
      Qingdao, P.R. China.
FAU - Li, Jing
AU  - Li J
AD  - Department of Anesthesiology, Qilu Hospital of Shandong University (Qingdao), 
      Qingdao, P.R. China.
FAU - Ji, Fucheng
AU  - Ji F
AD  - Department of Anesthesiology, Qilu Hospital of Shandong University (Qingdao), 
      Qingdao, P.R. China.
FAU - Tang, Wenxi
AU  - Tang W
AD  - Department of Anesthesiology, Qilu Hospital of Shandong University (Qingdao), 
      Qingdao, P.R. China.
FAU - Li, Jianjun
AU  - Li J
AD  - Department of Anesthesiology, Qilu Hospital of Shandong University (Qingdao), 
      Qingdao, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nicotine Tob Res
JT  - Nicotine & tobacco research : official journal of the Society for Research on 
      Nicotine and Tobacco
JID - 9815751
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NF-kappa B)
RN  - 6M3C89ZY6R (Nicotine)
RN  - EC 2.7.10.1 (Ntrk2 protein, rat)
RN  - EC 2.7.10.1 (Receptor, trkB)
MH  - Aging/drug effects/*metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognitive Dysfunction/drug therapy/*metabolism
MH  - Hepatectomy/adverse effects/trends
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - NF-kappa B/antagonists & inhibitors/*metabolism
MH  - Neuroprotection/*drug effects/physiology
MH  - Nicotine/*pharmacology/therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/*metabolism
MH  - Signal Transduction/drug effects/physiology
EDAT- 2017/10/25 06:00
MHDA- 2019/07/26 06:00
CRDT- 2017/10/25 06:00
PHST- 2016/12/20 00:00 [received]
PHST- 2017/07/10 00:00 [accepted]
PHST- 2017/10/25 06:00 [pubmed]
PHST- 2019/07/26 06:00 [medline]
PHST- 2017/10/25 06:00 [entrez]
AID - 3979270 [pii]
AID - 10.1093/ntr/ntx157 [doi]
PST - ppublish
SO  - Nicotine Tob Res. 2018 Mar 6;20(4):515-522. doi: 10.1093/ntr/ntx157.