PMID- 29065400
OWN - NLM
STAT- MEDLINE
DCOM- 20180727
LR  - 20180727
IS  - 1423-0224 (Electronic)
IS  - 0302-282X (Linking)
VI  - 75
IP  - 2
DP  - 2017
TI  - Dose-Dependent Effects of Binge-Like Methamphetamine Dosing on Dopamine and 
      Neurotrophin Levels in Rat Brain.
PG  - 63-71
LID - 10.1159/000480513 [doi]
AB  - This study investigated the acute effect of a dose range of low-to-moderate 
      binge-like methamphetamine treatments on the regional expression of neurotrophin 
      proteins in the brain and serum 2 h after the last dose, in addition to assessing 
      the behavioural effects and dopamine neurotransmitter changes produced. Male 
      Sprague-Dawley rats received 4 subcutaneous doses of methamphetamine (0.5, 1, 2, 
      and 4 mg/kg, or saline as a control) 2 h apart. Methamphetamine had a 
      dose-dependent stimulatory effect on locomotor activity over the 8 h of 
      observation. A significant increase in dopamine concentration was observed in the 
      frontal cortex with the highest dose of methamphetamine (2 h after the last 
      dose). This effect was dose- and region-specific, as no significant increase was 
      observed with lower doses, nor was a significant change observed in any other 
      brain region tested. A similar dose- and region-specific increase in 
      brain-derived neurotrophic factor (BDNF) was observed in the frontal cortex with 
      the highest-dose regimen. No significant change occurred with lower doses of 
      methamphetamine, or in any other brain region tested. A reduction in BDNF levels 
      in the serum was also observed with the highest concentration, but not with lower 
      doses. Collectively, this data highlights the importance of the frontal cortex in 
      methamphetamine-induced effects, and also the similar dose-response effect of 
      methamphetamine on dopamine and BDNF expression.
CI  - (c) 2017 S. Karger AG, Basel.
FAU - Moreira da Silva Santos, Andreia
AU  - Moreira da Silva Santos A
AD  - School of Medicine and Galway Neuroscience Centre, National University of 
      Ireland, Galway, Ireland.
FAU - Kelly, John P
AU  - Kelly JP
FAU - Doyle, Karen M
AU  - Doyle KM
LA  - eng
PT  - Journal Article
DEP - 20171024
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Nerve Growth Factors)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 44RAL3456C (Methamphetamine)
RN  - 46627O600J (Levodopa)
RN  - VTD58H1Z2X (Dopamine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Animals
MH  - Brain/*drug effects/metabolism
MH  - Central Nervous System Stimulants/*therapeutic use
MH  - Dopamine/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression Regulation/drug effects
MH  - Homovanillic Acid/metabolism
MH  - Levodopa/metabolism
MH  - Locomotion/drug effects
MH  - Male
MH  - Methamphetamine/*therapeutic use
MH  - Nerve Growth Factors/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Dopamine
OT  - Dose-dependent response
OT  - Frontal cortex
OT  - Methamphetamine
OT  - Neurotrophin
EDAT- 2017/10/25 06:00
MHDA- 2018/07/28 06:00
CRDT- 2017/10/25 06:00
PHST- 2017/04/26 00:00 [received]
PHST- 2017/08/21 00:00 [accepted]
PHST- 2017/10/25 06:00 [pubmed]
PHST- 2018/07/28 06:00 [medline]
PHST- 2017/10/25 06:00 [entrez]
AID - 000480513 [pii]
AID - 10.1159/000480513 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2017;75(2):63-71. doi: 10.1159/000480513. Epub 2017 Oct 24.