PMID- 29065422
OWN - NLM
STAT- MEDLINE
DCOM- 20180727
LR  - 20181113
IS  - 1423-0224 (Electronic)
IS  - 0302-282X (Print)
IS  - 0302-282X (Linking)
VI  - 75
IP  - 2
DP  - 2017
TI  - Acute Phencyclidine Alters Neural Oscillations Evoked by Tones in the Auditory 
      Cortex of Rats.
PG  - 53-62
LID - 10.1159/000480511 [doi]
AB  - BACKGROUND/AIMS: The onset response to a single tone as measured by 
      electroencephalography (EEG) is diminished in power and synchrony in 
      schizophrenia. Because neural synchrony, particularly at gamma frequencies (30-80 
      Hz), is hypothesized to be supported by the N-methyl-D-aspartate receptor (NMDAr) 
      system, we tested whether phencyclidine (PCP), an NMDAr antagonist, produced 
      similar deficits to tone stimuli in rats. METHODS: Experiment 1 tested the effect 
      of a PCP dose (1.0, 2.5, and 4.5 mg/kg) on response to single tones on 
      intracranial EEG recorded over the auditory cortex in rats. Experiment 2 
      evaluated the effect of PCP after acute administration of saline or PCP (5 
      mg/kg), after continuous subchronic administration of saline or PCP (5 
      mg/kg/day), and after a week of drug cessation. In both experiments, a 
      time-frequency analysis quantified mean power (MP) and phase locking factor (PLF) 
      between 1 and 80 Hz. Event-related potentials (ERPs) were also measured to tones, 
      and EEG spectral power in the absence of auditory stimuli. RESULTS: Acute PCP 
      increased PLF and MP between 10 and 30 Hz, while decreasing MP and PLF between 
      approximately 50 and 70 Hz. Acute PCP produced a dose-dependent broad-band 
      increase in EEG power that extended into gamma range frequencies. There were no 
      consistent effects of subchronic administration on gamma range activity. Acute 
      PCP increased ERP amplitudes for the P16 and N70 components. CONCLUSIONS: 
      Findings suggest that acute PCP-induced NMDAr hypofunction has differential 
      effects on neural power and synchrony which vary with dose, time course of 
      administration and EEG frequency. EEG synchrony and power appear to be sensitive 
      translational biomarkers for disrupted NMDAr function, which may contribute to 
      the pathophysiology of schizophrenia and other neuropsychiatric disorders.
CI  - (c) 2017 S. Karger AG, Basel.
FAU - Schnakenberg Martin, Ashley M
AU  - Schnakenberg Martin AM
AD  - Department of Psychological and Brain Sciences, Indiana University-Bloomington, 
      Bloomington, IN, USA.
FAU - O'Donnell, Brian F
AU  - O'Donnell BF
FAU - Millward, James B
AU  - Millward JB
FAU - Vohs, Jenifer L
AU  - Vohs JL
FAU - Leishman, Emma
AU  - Leishman E
FAU - Bolbecker, Amanda R
AU  - Bolbecker AR
FAU - Rass, Olga
AU  - Rass O
FAU - Morzorati, Sandra L
AU  - Morzorati SL
LA  - eng
GR  - R21 MH071876/MH/NIMH NIH HHS/United States
GR  - T32 DA024628/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20171024
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - J1DOI7UV76 (Phencyclidine)
SB  - IM
MH  - Acoustic Stimulation
MH  - Animals
MH  - Auditory Cortex/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Electroencephalography
MH  - Evoked Potentials, Auditory/*drug effects
MH  - Excitatory Amino Acid Antagonists/*pharmacology
MH  - Male
MH  - Phencyclidine/*pharmacology
MH  - Psychoacoustics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spectrum Analysis
MH  - Time Factors
PMC - PMC5752597
MID - NIHMS903971
OTO - NOTNLM
OT  - Auditory event-related potential
OT  - Neural synchrony
OT  - Phencyclidine
OT  - Rat model
OT  - Schizophrenia
EDAT- 2017/10/25 06:00
MHDA- 2018/07/28 06:00
PMCR- 2018/10/24
CRDT- 2017/10/25 06:00
PHST- 2016/09/01 00:00 [received]
PHST- 2017/08/21 00:00 [accepted]
PHST- 2017/10/25 06:00 [pubmed]
PHST- 2018/07/28 06:00 [medline]
PHST- 2017/10/25 06:00 [entrez]
PHST- 2018/10/24 00:00 [pmc-release]
AID - 000480511 [pii]
AID - 10.1159/000480511 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2017;75(2):53-62. doi: 10.1159/000480511. Epub 2017 Oct 24.