PMID- 29067329
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240328
IS  - 2352-8737 (Print)
IS  - 2352-8737 (Electronic)
IS  - 2352-8737 (Linking)
VI  - 3
IP  - 2
DP  - 2017 Jun
TI  - Associations between social relationship measures, serum brain-derived 
      neurotrophic factor, and risk of stroke and dementia.
PG  - 229-237
LID - 10.1016/j.trci.2017.03.001 [doi]
AB  - INTRODUCTION: Mechanisms underlying social determinants of stroke and dementia 
      are unclear and brain-derived neurotrophic factor (BDNF) may contribute as a 
      molecular link. METHODS: Using the Framingham Study, we examined social 
      relationship measures as predictors of higher serum BDNF level and cumulative 
      incidence of stroke and dementia. RESULTS: Among 3294 participants, controlling 
      for age and sex, isolation trended with lower BDNF (odds ratio = 0.69 
      [0.47-1.00]). Participants with more companionship had reduced risk for stroke 
      (hazard ratio [HR] = 0.59 [0.41-0.83]) and dementia (HR = 0.67 [0.49-0.92]). 
      Greater emotional support was associated with higher BDNF (odds ratio = 1.27 
      [1.04-1.54]), reduced dementia risk (HR = 0.69 [0.51-0.94], and among smokers, 
      reduced stroke risk (HR = 0.23 [0.10-0.57]). Associations persisted after 
      additional adjustments. BDNF partly mediated the total effect between emotional 
      support and dementia risk. CONCLUSIONS: Availability of social support appears to 
      be associated with increased BDNF levels and, in certain subsets, reduce risk of 
      subsequent dementia and stroke, thus warranting study of these pathways to 
      understand their role in neuroprotection.
FAU - Salinas, Joel
AU  - Salinas J
AD  - Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 
      Boston, MA, USA.
AD  - The Framingham Heart Study, Boston, MA, USA.
AD  - Department of Epidemiology, Harvard Center for Population and Development 
      Studies, Harvard TH Chan School of Public Health, Boston, MA, USA.
AD  - Department of Social and Behavioral Sciences, Harvard Center for Population and 
      Development Studies, Harvard TH Chan School of Public Health, Boston, MA, USA.
FAU - Beiser, Alexa
AU  - Beiser A
AD  - The Framingham Heart Study, Boston, MA, USA.
AD  - Department of Biostatistics, Boston University School of Public Health, Boston, 
      MA, USA.
AD  - Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
FAU - Himali, Jayandra J
AU  - Himali JJ
AD  - The Framingham Heart Study, Boston, MA, USA.
AD  - Department of Biostatistics, Boston University School of Public Health, Boston, 
      MA, USA.
AD  - Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
FAU - Satizabal, Claudia L
AU  - Satizabal CL
AD  - The Framingham Heart Study, Boston, MA, USA.
AD  - Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
FAU - Aparicio, Hugo J
AU  - Aparicio HJ
AD  - The Framingham Heart Study, Boston, MA, USA.
AD  - Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
FAU - Weinstein, Galit
AU  - Weinstein G
AD  - The Framingham Heart Study, Boston, MA, USA.
AD  - School of Public Health, University of Haifa, Haifa, Israel.
FAU - Mateen, Farrah J
AU  - Mateen FJ
AD  - Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 
      Boston, MA, USA.
FAU - Berkman, Lisa F
AU  - Berkman LF
AD  - Department of Epidemiology, Harvard Center for Population and Development 
      Studies, Harvard TH Chan School of Public Health, Boston, MA, USA.
AD  - Department of Social and Behavioral Sciences, Harvard Center for Population and 
      Development Studies, Harvard TH Chan School of Public Health, Boston, MA, USA.
FAU - Rosand, Jonathan
AU  - Rosand J
AD  - Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 
      Boston, MA, USA.
AD  - Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA, 
      USA.
FAU - Seshadri, Sudha
AU  - Seshadri S
AD  - The Framingham Heart Study, Boston, MA, USA.
AD  - Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
LA  - eng
GR  - R01 NS017950/NS/NINDS NIH HHS/United States
GR  - R01 AG054076/AG/NIA NIH HHS/United States
GR  - HHSN268201500001C/HL/NHLBI NIH HHS/United States
GR  - N01 HC025195/HC/NHLBI NIH HHS/United States
GR  - T32 NS048005/NS/NINDS NIH HHS/United States
GR  - R01 AG008122/AG/NIA NIH HHS/United States
GR  - R01 AG033193/AG/NIA NIH HHS/United States
GR  - HHSN268201500001I/HL/NHLBI NIH HHS/United States
GR  - N01HC25195/HL/NHLBI NIH HHS/United States
GR  - P30 AG010129/AG/NIA NIH HHS/United States
GR  - R01 AG031287/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20170322
PL  - United States
TA  - Alzheimers Dement (N Y)
JT  - Alzheimer's & dementia (New York, N. Y.)
JID - 101650118
PMC - PMC5651441
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Cohort studies
OT  - Dementia
OT  - Epidemiology
OT  - Social networks
OT  - Social relationships
OT  - Social support
OT  - Stroke
EDAT- 2017/10/27 06:00
MHDA- 2017/10/27 06:01
PMCR- 2017/03/22
CRDT- 2017/10/26 06:00
PHST- 2017/10/26 06:00 [entrez]
PHST- 2017/10/27 06:00 [pubmed]
PHST- 2017/10/27 06:01 [medline]
PHST- 2017/03/22 00:00 [pmc-release]
AID - S2352-8737(17)30012-4 [pii]
AID - 10.1016/j.trci.2017.03.001 [doi]
PST - epublish
SO  - Alzheimers Dement (N Y). 2017 Mar 22;3(2):229-237. doi: 
      10.1016/j.trci.2017.03.001. eCollection 2017 Jun.