PMID- 29067994
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20230203
IS  - 1935-3456 (Electronic)
IS  - 1933-0219 (Linking)
VI  - 11
IP  - 3
DP  - 2018 May
TI  - Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty 
      acids.
PG  - 785-795
LID - 10.1038/mi.2017.75 [doi]
AB  - The mammalian gastrointestinal tract harbors a microbial community with metabolic 
      activity critical for host health, including metabolites that can modulate 
      effector functions of immune cells. Mice treated with vancomycin have an altered 
      microbiome and metabolite profile, exhibit exacerbated T helper type 2 cell (Th2) 
      responses, and are more susceptible to allergic lung inflammation. Here we show 
      that dietary supplementation with short-chain fatty acids (SCFAs) ameliorates 
      this enhanced asthma susceptibility by modulating the activity of T cells and 
      dendritic cells (DCs). Dysbiotic mice treated with SCFAs have fewer interleukin-4 
      (IL4)-producing CD4(+) T cells and decreased levels of circulating immunoglobulin 
      E (IgE). In addition, DCs exposed to SCFAs activate T cells less robustly, are 
      less motile in response to CCL19 in vitro, and exhibit a dampened ability to 
      transport inhaled allergens to lung draining nodes. Our data thus demonstrate 
      that gut dysbiosis can exacerbate allergic lung inflammation through both T cell- 
      and DC-dependent mechanisms that are inhibited by SCFAs.
FAU - Cait, A
AU  - Cait A
AD  - Department of Microbiology and Immunology, Life Sciences Institute, University of 
      British Columbia, Vancouver, British Columbia, Canada.
FAU - Hughes, M R
AU  - Hughes MR
AD  - The Biomedical Research Centre, University of British Columbia, Vancouver, 
      British Columbia, Canada.
FAU - Antignano, F
AU  - Antignano F
AD  - The Biomedical Research Centre, University of British Columbia, Vancouver, 
      British Columbia, Canada.
FAU - Cait, J
AU  - Cait J
AD  - The Biomedical Research Centre, University of British Columbia, Vancouver, 
      British Columbia, Canada.
FAU - Dimitriu, P A
AU  - Dimitriu PA
AD  - Department of Microbiology and Immunology, Life Sciences Institute, University of 
      British Columbia, Vancouver, British Columbia, Canada.
FAU - Maas, K R
AU  - Maas KR
AD  - Department of Microbiology and Immunology, Life Sciences Institute, University of 
      British Columbia, Vancouver, British Columbia, Canada.
FAU - Reynolds, L A
AU  - Reynolds LA
AD  - Michael Smith Laboratories, University of British Columbia, Vancouver, British 
      Columbia, Canada.
FAU - Hacker, L
AU  - Hacker L
AD  - The Biomedical Research Centre, University of British Columbia, Vancouver, 
      British Columbia, Canada.
FAU - Mohr, J
AU  - Mohr J
AD  - The Biomedical Research Centre, University of British Columbia, Vancouver, 
      British Columbia, Canada.
FAU - Finlay, B B
AU  - Finlay BB
AD  - Department of Microbiology and Immunology, Life Sciences Institute, University of 
      British Columbia, Vancouver, British Columbia, Canada.
AD  - Michael Smith Laboratories, University of British Columbia, Vancouver, British 
      Columbia, Canada.
AD  - Department of Biochemistry and Molecular Biology, University of British Columbia, 
      Vancouver, British Columbia, Canada.
FAU - Zaph, C
AU  - Zaph C
AD  - Department of Pathology and Laboratory Medicine, University of British Columbia, 
      Vancouver, British Columbia, Canada.
AD  - Biomedicine Discovery Institute, Department of Biochemistry and Molecular 
      Biology, Monash University, Clayton, Victoria, Australia.
FAU - McNagny, K M
AU  - McNagny KM
AD  - The Biomedical Research Centre, University of British Columbia, Vancouver, 
      British Columbia, Canada.
AD  - Department of Medical Genetics, University of British Columbia, Vancouver, 
      British Columbia, Canada.
FAU - Mohn, W W
AU  - Mohn WW
AD  - Department of Microbiology and Immunology, Life Sciences Institute, University of 
      British Columbia, Vancouver, British Columbia, Canada.
LA  - eng
PT  - Journal Article
DEP - 20171025
PL  - United States
TA  - Mucosal Immunol
JT  - Mucosal immunology
JID - 101299742
RN  - 0 (Allergens)
RN  - 0 (Ccl19 protein, mouse)
RN  - 0 (Chemokine CCL19)
RN  - 0 (Fatty Acids, Volatile)
RN  - 207137-56-2 (Interleukin-4)
RN  - 6Q205EH1VU (Vancomycin)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Antigen Presentation
MH  - Asthma/*immunology/prevention & control
MH  - Chemokine CCL19/metabolism
MH  - Dendritic Cells/*immunology
MH  - Dietary Supplements
MH  - Dysbiosis/*immunology/prevention & control
MH  - Fatty Acids, Volatile/*administration & dosage
MH  - Gastrointestinal Microbiome/immunology
MH  - Hypersensitivity/*immunology/prevention & control
MH  - Interleukin-4/genetics/metabolism
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Microbiota/immunology
MH  - Pneumonia/*immunology/prevention & control
MH  - Th2 Cells/*immunology
MH  - Vancomycin/administration & dosage
EDAT- 2017/10/27 06:00
MHDA- 2018/12/12 06:00
CRDT- 2017/10/26 06:00
PHST- 2016/12/19 00:00 [received]
PHST- 2017/07/26 00:00 [accepted]
PHST- 2017/10/27 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2017/10/26 06:00 [entrez]
AID - S1933-0219(22)00552-9 [pii]
AID - 10.1038/mi.2017.75 [doi]
PST - ppublish
SO  - Mucosal Immunol. 2018 May;11(3):785-795. doi: 10.1038/mi.2017.75. Epub 2017 Oct 
      25.