PMID- 29070273
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2152-6575 (Print)
IS  - 2152-6567 (Electronic)
IS  - 2152-6567 (Linking)
VI  - 8
IP  - 3
DP  - 2017 Oct 1
TI  - Oral immunotherapy in children with IgE-mediated hen's egg allergy: Follow-ups at 
      2.5 and 7 years.
PG  - 157-169
LID - 10.2500/ar.2017.8.0211 [doi]
AB  - BACKGROUND: The present report was a follow-up investigation at 2.5- and 7-year 
      intervals of a previous study of 20 children with moderate-to-severe 
      immunoglobulin E (IgE) mediated hen's egg (HE) allergy who received oral 
      immunotherapy (OIT) with raw HE. The study design of the previous study divided 
      the 20 subjects into two groups of 10 each: (1) group 1, the OIT group (OIT-G), 
      and, (2) group 2, an age-matched control group (C-G). In that study, 8 of 10 of 
      the children in the OIT-G were successfully desensitized, one child was partially 
      desensitized, and desensitization failed in one child. The aims of the present 
      study were to evaluate the long-term effectiveness and safety profile of OIT with 
      raw HE, and to assess the course and prognostic value of skin-prick tests (SPT) 
      and serum-specific HE-IgEs in this study population. METHODS: Of the 20 children 
      who were recalled, 2 dropped out, which left 18 to be evaluated. Information on 
      their HE intake was recorded, and SPTs with HE allergen extracts and with raw and 
      hard-boiled HE were performed. Ovomucoid- and ovalbumin-specific IgE levels were 
      also measured. RESULTS: At the first (2.5-year) and second (7-year) follow-ups, 
      87.5% of the children in the OIT-G who tolerated raw HE were still tolerant, 
      whereas the children in the C-G were significantly less tolerant. Overall, 
      cutaneous sensitivity to HE significantly decreased after the 6-month 
      desensitization period and at both follow-ups with regard to the OIT-G but not 
      with regard to the C-G. A significant reduction in serum ovomucoid- and 
      ovalbumin-specific IgE levels was seen in both the OIT-G and the C-G. CONCLUSION: 
      Clinical raw HE tolerance induced by OIT persists over time. Negativization of 
      SPTs could be considered a more reliable prognostic indicator of clinical 
      tolerance to raw HE than the reduction in specific-HE IgE levels. Raw-HE OIT 
      would seem to be a promising method to treat HE allergy.
FAU - Meglio, Paolo
AU  - Meglio P
AD  - From the San Pietro Hospital, Fatebenefratelli Research Center, Rome, Italy.
FAU - Giampietro, Paolo Gianni
AU  - Giampietro PG
AD  - From the San Pietro Hospital, Fatebenefratelli Research Center, Rome, Italy.
FAU - Carello, Rossella
AU  - Carello R
AD  - From the San Pietro Hospital, Fatebenefratelli Research Center, Rome, Italy.
FAU - Galli, Elena
AU  - Galli E
AD  - From the San Pietro Hospital, Fatebenefratelli Research Center, Rome, Italy.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Rhinol (Providence)
JT  - Allergy & rhinology (Providence, R.I.)
JID - 101570968
PMC - PMC5662541
COIS- The authors have no conflicts of interest to declare pertaining to this article
EDAT- 2017/10/27 06:00
MHDA- 2017/10/27 06:01
PMCR- 2017/10/01
CRDT- 2017/10/27 06:00
PHST- 2017/10/27 06:00 [entrez]
PHST- 2017/10/27 06:00 [pubmed]
PHST- 2017/10/27 06:01 [medline]
PHST- 2017/10/01 00:00 [pmc-release]
AID - AR093-16 [pii]
AID - 10.2500/ar.2017.8.0211 [doi]
PST - ppublish
SO  - Allergy Rhinol (Providence). 2017 Oct 1;8(3):157-169. doi: 
      10.2500/ar.2017.8.0211.