PMID- 2907115
OWN - NLM
STAT- MEDLINE
DCOM- 19890502
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 27
IP  - 10
DP  - 1988 Oct
TI  - Antagonism of dermorphin-induced catalepsy with naloxone, TRH-analog CG3703 and 
      the benzodiazepine antagonist, Ro 15-1788.
PG  - 1007-12
AB  - Intracerebroventricular (i.c.v.) administration of the highly selective opiate 
      mu-receptor agonist, dermorphin, produced dose-dependent catalepsy in conscious 
      rats. The cataleptic effect of dermorphin was abolished by pretreatment 
      (intraperitoneal, i.p.) with the opiate-antagonist naloxone (5 mg/kg), 
      thyrotropin-releasing hormone analog CG3703 (1 mg/kg) or the 
      benzodiazepine-antagonist Ro 15-1788 (5 mg/kg) whereas pretreatment with the 
      benzodiazepine alprazolam (1 mg/kg) potentiated the cataleptic effect of 
      dermorphin. When given to cataleptic rats, naloxone and CG3703, but not Ro 
      15-1788, reversed the dermorphin-induced catalepsy. The data suggest an 
      involvement of benzodiazepine receptors in the induction of catalepsy mediated by 
      opioid mu-receptors. Other opioid-modulating neuronal systems, antagonized by 
      CG3703, may be involved in maintaining the dermorphin-induced cataleptic state.
FAU - Paakkari, P
AU  - Paakkari P
AD  - Department of Neurology, Uniformed Services University of the Health Sciences, 
      Bethesda, Maryland 20814.
FAU - Feuerstein, G
AU  - Feuerstein G
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Oligopeptides)
RN  - 0 (Opioid Peptides)
RN  - 2SEC01B703 (dermorphin)
RN  - 30MUJ6YYUY (montirelin)
RN  - 36B82AMQ7N (Naloxone)
RN  - 40P7XK9392 (Flumazenil)
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
RN  - YU55MQ3IZY (Alprazolam)
SB  - IM
MH  - Alprazolam/pharmacology
MH  - Analgesics, Opioid/*antagonists & inhibitors/toxicity
MH  - Animals
MH  - Catalepsy/*chemically induced
MH  - Flumazenil/*pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Naloxone/*pharmacology
MH  - Oligopeptides/administration & dosage/*antagonists & inhibitors/toxicity
MH  - Opioid Peptides
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Thyrotropin-Releasing Hormone/*analogs & derivatives/pharmacology
EDAT- 1988/10/01 00:00
MHDA- 1988/10/01 00:01
CRDT- 1988/10/01 00:00
PHST- 1988/10/01 00:00 [pubmed]
PHST- 1988/10/01 00:01 [medline]
PHST- 1988/10/01 00:00 [entrez]
AID - 10.1016/0028-3908(88)90060-3 [doi]
PST - ppublish
SO  - Neuropharmacology. 1988 Oct;27(10):1007-12. doi: 10.1016/0028-3908(88)90060-3.