PMID- 29071507
OWN - NLM
STAT- MEDLINE
DCOM- 20180925
LR  - 20190402
IS  - 0171-2004 (Print)
IS  - 0171-2004 (Linking)
VI  - 246
DP  - 2018
TI  - Posttranslational Modification of Sodium Channels.
PG  - 101-124
LID - 10.1007/164_2017_69 [doi]
AB  - Voltage-gated sodium channels (VGSCs) are critical determinants of excitability. 
      The properties of VGSCs are thought to be tightly controlled. However, VGSCs are 
      also subjected to extensive modifications. Multiple posttranslational 
      modifications that covalently modify VGSCs in neurons and muscle have been 
      identified. These include, but are not limited to, phosphorylation, 
      ubiquitination, palmitoylation, nitrosylation, glycosylation, and SUMOylation. 
      Posttranslational modifications of VGSCs can have profound impact on cellular 
      excitability, contributing to normal and abnormal physiology. Despite four 
      decades of research, the complexity of VGSC modulation is still being determined. 
      While some modifications have similar effects on the various VGSC isoforms, 
      others have isoform-specific interactions. In addition, while much has been 
      learned about how individual modifications can impact VGSC function, there is 
      still more to be learned about how different modifications can interact. Here we 
      review what is known about VGSC posttranslational modifications with a focus on 
      the breadth and complexity of the regulatory mechanisms that impact VGSC 
      properties.
FAU - Pei, Zifan
AU  - Pei Z
AD  - Department of Biology, Indiana University - Purdue University Indianapolis, 
      Indianapolis, IN, USA.
AD  - Department of Pharmacology and Toxicology, Indiana University - Purdue University 
      Indianapolis, Indianapolis, IN, USA.
FAU - Pan, Yanling
AU  - Pan Y
AD  - Medical Neuroscience Graduate Program, Indiana University - Purdue University 
      Indianapolis, Indianapolis, IN, USA.
FAU - Cummins, Theodore R
AU  - Cummins TR
AD  - Department of Biology, Indiana University - Purdue University Indianapolis, 
      Indianapolis, IN, USA. trcummin@iupui.edu.
AD  - Department of Pharmacology and Toxicology, Indiana University - Purdue University 
      Indianapolis, Indianapolis, IN, USA. trcummin@iupui.edu.
AD  - Medical Neuroscience Graduate Program, Indiana University - Purdue University 
      Indianapolis, Indianapolis, IN, USA. trcummin@iupui.edu.
LA  - eng
GR  - R01 NS053422/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Handb Exp Pharmacol
JT  - Handbook of experimental pharmacology
JID - 7902231
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Voltage-Gated Sodium Channels)
SB  - IM
MH  - Animals
MH  - Glycosylation
MH  - Humans
MH  - Phosphorylation
MH  - *Protein Processing, Post-Translational
MH  - Reactive Oxygen Species/metabolism
MH  - Sumoylation
MH  - Ubiquitination
MH  - Voltage-Gated Sodium Channels/*metabolism
OTO - NOTNLM
OT  - Nav
OT  - Nitrosylation
OT  - Palmitoylation
OT  - Phosphorylation
EDAT- 2017/10/27 06:00
MHDA- 2018/09/27 06:00
CRDT- 2017/10/27 06:00
PHST- 2017/10/27 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2017/10/27 06:00 [entrez]
AID - 10.1007/164_2017_69 [doi]
PST - ppublish
SO  - Handb Exp Pharmacol. 2018;246:101-124. doi: 10.1007/164_2017_69.