PMID- 29071937
OWN - NLM
STAT- MEDLINE
DCOM- 20180111
LR  - 20180111
IS  - 1000-0607 (Print)
IS  - 1000-0607 (Linking)
VI  - 41
IP  - 4
DP  - 2016 Aug 25
TI  - [Involvement of Central Neuroglia Cells in Analgesic Effect of Electroacupuncture 
      Therapy for Neuropathic Pain].
PG  - 369-372
AB  - Neuropathic pain is one of the common chronic syndromes in clinical practice. It 
      has been demonstrated that the chronic neuropathic pain and glial cells in the 
      central nervous system are closely related to each other. When inducing analgesic 
      effect in neuropathic pain, EA suppressed OX-42 labeled activation of 
      microgliacytes in dorsal horns of the spinal cord, down-regulated release of 
      nitric oxide (NO), expression of P 2 X(4) receptor, intracellular 
      mitogen-activated protein kinase (MAPK), extracellular regulated protein kinases 
      (ERK), proinflammatory cytokines IL-1 beta, IL-6, TNF-alpha, interferon (IF)-gamma and 
      up-regulated neurotrophin-3 expression in neuropathic pain rats. In regard to 
      spinal astrocytes, acupuncture suppressed peripheral nerve injury induced 
      activation of GFAP-labeled astrocytes, down-regulated the expression levels of 
      macrophage inflammatory proteins (MIP)-1, MIP-1 beta, MIP-3 alpha, TNF-alpha mRNA and IL-1 beta 
      mRNA, etc. in the dorsal horns of the spinal cord. Up to now, the underlying 
      me-chanisms of acupuncture in regulating activities of glia cells, and 
      interaction between neurons and glia cells, and the related pathways in the 
      peripheral and central systems remain unclear. The effects of some related 
      protein and gene expressions involving in acupuncture analgesia need being 
      confirmed by adopting different approaches.
FAU - Li, Si-Si
AU  - Li SS
AD  - The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, 
      China.
FAU - Tu, Wen-Zhan
AU  - Tu WZ
AD  - The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, 
      China.
FAU - Zhong, Yan-Biao
AU  - Zhong YB
AD  - The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, 
      China.
FAU - Jiang, Xia
AU  - Jiang X
AD  - The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, 
      China.
FAU - Jiang, Song-He
AU  - Jiang SH
AD  - The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, 
      China. jshwz@126.com.
LA  - chi
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhen Ci Yan Jiu
JT  - Zhen ci yan jiu = Acupuncture research
JID - 8507710
RN  - 0 (Interleukin-1beta)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - *Acupuncture Analgesia
MH  - Animals
MH  - *Electroacupuncture
MH  - Humans
MH  - Interleukin-1beta/genetics/metabolism
MH  - Neuralgia/genetics/metabolism/*therapy
MH  - Neuroglia/*metabolism
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
EDAT- 2016/08/25 00:00
MHDA- 2018/01/13 06:00
CRDT- 2017/10/27 06:00
PHST- 2017/10/27 06:00 [entrez]
PHST- 2016/08/25 00:00 [pubmed]
PHST- 2018/01/13 06:00 [medline]
PST - ppublish
SO  - Zhen Ci Yan Jiu. 2016 Aug 25;41(4):369-372.