PMID- 29075103
OWN - NLM
STAT- MEDLINE
DCOM- 20180723
LR  - 20220330
IS  - 1177-8881 (Electronic)
IS  - 1177-8881 (Linking)
VI  - 11
DP  - 2017
TI  - Amelioration of collagen-induced arthritis using antigen-loaded dendritic cells 
      modified with NF-kappaB decoy oligodeoxynucleotides.
PG  - 2997-3007
LID - 10.2147/DDDT.S145421 [doi]
AB  - Dendritic cells (DCs) play an important role in the initiation of autoimmunity in 
      rheumatoid arthritis (RA); therefore, the use of DCs needs to be explored to 
      develop new therapeutic approaches for RA. Here, we investigated the therapeutic 
      effect of bovine type II collagen (BIIC)-loaded DCs modified with NF-kappaB decoy 
      oligodeoxynucleotides (ODNs) on collagen-induced arthritis (CIA) in rats and 
      explored the underlying mechanisms. DCs treated with BIIC and NF-kappaB decoy ODNs 
      exhibited features of immature DCs with low levels of costimulatory molecule 
      (CD80 and CD86) expression. The development of arthritis in rats with CIA 
      injected with BIIC + NF-kappaB decoy ODN-propagated DCs (BIIC-decoy DCs) was 
      significantly ameliorated compared to that in rats injected with BIIC-propagated 
      DCs or phosphate-buffered saline. We also found that the BIIC-decoy DCs exerted 
      antiarthritis effects by inhibiting self-lymphocyte proliferative response and 
      suppressing IFN-gamma and anti-BIIC antibody production and inducing IL-10 antibody 
      production. Additionally, antihuman serum antibodies were successfully produced 
      in the rats treated with BIIC-decoy DCs but not in those treated with NF-kappaB decoy 
      ODN-propagated DCs; moreover, the BIIC-decoy DCs did not affect immune function 
      in the normal rats. These findings suggested that NF-kappaB decoy ODN-modified DCs 
      loaded with a specific antigen might offer a practical method for the treatment 
      of human RA.
FAU - Jiang, Hongmei
AU  - Jiang H
AD  - School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, 
      Guizhou.
FAU - Hu, Henggui
AU  - Hu H
AD  - Department of Clinical Laboratory, The Third Hospital Subsidiary of Bengbu 
      Medical College, Suzhou, Anhui.
FAU - Zhang, Yali
AU  - Zhang Y
AD  - School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, 
      Guizhou.
FAU - Yue, Ping
AU  - Yue P
AD  - School of Biology and Engineering, Guizhou Medical University, Guiyang, Guizhou, 
      People's Republic of China.
FAU - Ning, Lichang
AU  - Ning L
AD  - School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, 
      Guizhou.
FAU - Zhou, Yan
AU  - Zhou Y
AD  - School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, 
      Guizhou.
FAU - Shi, Ping
AU  - Shi P
AD  - School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, 
      Guizhou.
FAU - Yuan, Rui
AU  - Yuan R
AD  - School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, 
      Guizhou.
LA  - eng
PT  - Journal Article
DEP - 20171013
PL  - New Zealand
TA  - Drug Des Devel Ther
JT  - Drug design, development and therapy
JID - 101475745
RN  - 0 (Antibodies)
RN  - 0 (B7-1 Antigen)
RN  - 0 (B7-2 Antigen)
RN  - 0 (Collagen Type II)
RN  - 0 (NF-kappaB decoy)
RN  - 0 (Oligodeoxyribonucleotides)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Animals
MH  - Antibodies/immunology
MH  - Arthritis, Experimental/immunology/*therapy
MH  - Arthritis, Rheumatoid/immunology/*therapy
MH  - B7-1 Antigen/immunology
MH  - B7-2 Antigen/immunology
MH  - Cattle
MH  - Collagen Type II/immunology
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Humans
MH  - Interleukin-10/immunology
MH  - Oligodeoxyribonucleotides/*administration & dosage/immunology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Rats, Wistar
PMC - PMC5648311
OTO - NOTNLM
OT  - NF-kappaB decoy oligodeoxynucleotides
OT  - collagen-induced arthritis
OT  - dendritic cells
OT  - rheumatoid arthritis
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2017/10/28 06:00
MHDA- 2018/07/24 06:00
PMCR- 2017/10/13
CRDT- 2017/10/28 06:00
PHST- 2017/10/28 06:00 [entrez]
PHST- 2017/10/28 06:00 [pubmed]
PHST- 2018/07/24 06:00 [medline]
PHST- 2017/10/13 00:00 [pmc-release]
AID - dddt-11-2997 [pii]
AID - 10.2147/DDDT.S145421 [doi]
PST - epublish
SO  - Drug Des Devel Ther. 2017 Oct 13;11:2997-3007. doi: 10.2147/DDDT.S145421. 
      eCollection 2017.