PMID- 29075536
OWN - NLM
STAT- MEDLINE
DCOM- 20180622
LR  - 20181113
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2017
DP  - 2017
TI  - Neural Plasticity Associated with Hippocampal PKA-CREB and NMDA Signaling Is 
      Involved in the Antidepressant Effect of Repeated Low Dose of Yueju Pill on 
      Chronic Mouse Model of Learned Helplessness.
PG  - 9160515
LID - 10.1155/2017/9160515 [doi]
LID - 9160515
AB  - Yueju pill is a traditional Chinese medicine formulated to treat syndromes of 
      mood disorders. Here, we investigated the therapeutic effect of repeated low dose 
      of Yueju in the animal model mimicking clinical long-term depression condition 
      and the role of neural plasticity associated with PKA- (protein kinase A-) CREB 
      (cAMP response element binding protein) and NMDA (N-methyl-D-aspartate) 
      signaling. We showed that a single low dose of Yueju demonstrated antidepressant 
      effects in tests of tail suspension, forced swim, and novelty-suppressed feeding. 
      A chronic learned helplessness (LH) protocol resulted in a long-term 
      depressive-like condition. Repeated administration of Yueju following chronic LH 
      remarkably alleviated all of depressive-like symptoms measured, whereas 
      conventional antidepressant fluoxetine only showed a minor improvement. In the 
      hippocampus, Yueju and fluoxetine both normalized brain-derived neurotrophic 
      factor (BDNF) and PKA level. Only Yueju, not fluoxetine, rescued the deficits in 
      CREB signaling. The chronic LH upregulated the expression of NMDA receptor 
      subunits NR1, NR2A, and NR2B, which were all attenuated by Yueju. Furthermore, 
      intracerebraventricular administration of NMDA blunted the antidepressant effect 
      of Yueju. These findings supported the antidepressant efficacy of repeated 
      routine low dose of Yueju in a long-term depression model and the critical role 
      of CREB and NMDA signaling.
FAU - Zou, Zhilu
AU  - Zou Z
AD  - Center for Translational Systems Biology and Neuroscience and Key Laboratory of 
      Integrative Biomedicine for Brain Diseases, Nanjing University of Chinese 
      Medicine, Nanjing 210023, China.
FAU - Chen, Yin
AU  - Chen Y
AD  - Center for Translational Systems Biology and Neuroscience and Key Laboratory of 
      Integrative Biomedicine for Brain Diseases, Nanjing University of Chinese 
      Medicine, Nanjing 210023, China.
FAU - Shen, Qinqin
AU  - Shen Q
AD  - Center for Translational Systems Biology and Neuroscience and Key Laboratory of 
      Integrative Biomedicine for Brain Diseases, Nanjing University of Chinese 
      Medicine, Nanjing 210023, China.
FAU - Guo, Xiaoyan
AU  - Guo X
AD  - Center for Translational Systems Biology and Neuroscience and Key Laboratory of 
      Integrative Biomedicine for Brain Diseases, Nanjing University of Chinese 
      Medicine, Nanjing 210023, China.
FAU - Zhang, Yuxuan
AU  - Zhang Y
AD  - Center for Translational Systems Biology and Neuroscience and Key Laboratory of 
      Integrative Biomedicine for Brain Diseases, Nanjing University of Chinese 
      Medicine, Nanjing 210023, China.
FAU - Chen, Gang
AU  - Chen G
AUID- ORCID: 0000-0002-3894-6294
AD  - Center for Translational Systems Biology and Neuroscience and Key Laboratory of 
      Integrative Biomedicine for Brain Diseases, Nanjing University of Chinese 
      Medicine, Nanjing 210023, China.
LA  - eng
PT  - Journal Article
DEP - 20170917
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
RN  - 0 (Antidepressive Agents)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Yueju-Wan)
RN  - EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology/therapeutic use
MH  - Cyclic AMP Response Element-Binding Protein/*metabolism
MH  - Cyclic AMP-Dependent Protein Kinases/*metabolism
MH  - Depression/drug therapy/metabolism
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/*pharmacology/therapeutic use
MH  - Female
MH  - *Helplessness, Learned
MH  - Male
MH  - Mice
MH  - Neuronal Plasticity/*drug effects/physiology
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Signal Transduction/*drug effects
MH  - Treatment Outcome
MH  - Up-Regulation/drug effects
PMC - PMC5623799
EDAT- 2017/10/28 06:00
MHDA- 2018/06/23 06:00
PMCR- 2017/09/17
CRDT- 2017/10/28 06:00
PHST- 2017/04/15 00:00 [received]
PHST- 2017/07/16 00:00 [revised]
PHST- 2017/08/03 00:00 [accepted]
PHST- 2017/10/28 06:00 [entrez]
PHST- 2017/10/28 06:00 [pubmed]
PHST- 2018/06/23 06:00 [medline]
PHST- 2017/09/17 00:00 [pmc-release]
AID - 10.1155/2017/9160515 [doi]
PST - ppublish
SO  - Neural Plast. 2017;2017:9160515. doi: 10.1155/2017/9160515. Epub 2017 Sep 17.