PMID- 29075538
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2090-6560 (Print)
IS  - 2090-6579 (Electronic)
IS  - 2090-6579 (Linking)
VI  - 2017
DP  - 2017
TI  - An Unsuspected Finding of t(9;22): A Rare Case of Philadelphia 
      Chromosome-Positive B-Lymphoblastic Lymphoma.
PG  - 2413587
LID - 10.1155/2017/2413587 [doi]
LID - 2413587
AB  - While rare, cases of isolated extramedullary disease of B-cell Lymphoblastic 
      Lymphoma (B-LBL) without morphologic bone marrow involvement have been described. 
      In this report, we illustrate the case of an elderly gentleman who presented with 
      isolated testicular and vertebral LBL involvement but had no morphologic bone 
      marrow involvement. The initial plan of treatment was to treat along the lines of 
      Philadelphia negative B-ALL/LBL. During this time, fluorescence in situ 
      hybridization (FISH) and PCR testing for BCR-ABL1 rearrangements were being 
      performed on the marrow specimens as a part of routine diagnostic workup. While 
      the FISH returned negative, PCR testing unexpectedly detected BCR-ABL1 fusion 
      transcripts at a low level of 0.48%. Given their presence, we performed FISH for 
      BCR/ABL1 rearrangement in both testicular and L5 vertebral specimens which were 
      80-90% positive. He subsequently received rituximab, hyper-CVAD, and dasatinib, 
      along with prophylactic intrathecal prophylactic chemotherapy. The patient 
      achieved a prolonged remission but eventually relapsed, 4 years later. Had it not 
      been for this fortuitous discovery, the patient would not have been treated with 
      tyrosine kinase inhibitors. We emphasize that FISH and PCR testing for BCR-ABL1 
      rearrangement are integral to arriving at an accurate diagnosis and should be 
      routinely tested on B-LBL biopsy specimens.
FAU - Boddu, Prajwal
AU  - Boddu P
AUID- ORCID: 0000-0003-4594-1704
AD  - Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX, USA.
FAU - Yin, C Cameron
AU  - Yin CC
AUID- ORCID: 0000-0001-6630-4128
AD  - Department of Hematopathology, UT MD Anderson Cancer Center, Houston, TX, USA.
FAU - Kanagal-Shamanna, Rashmi
AU  - Kanagal-Shamanna R
AD  - Department of Hematopathology, UT MD Anderson Cancer Center, Houston, TX, USA.
FAU - Tang, Guillin
AU  - Tang G
AUID- ORCID: 0000-0002-9482-4806
AD  - Department of Hematopathology, UT MD Anderson Cancer Center, Houston, TX, USA.
FAU - Thakral, Beenu
AU  - Thakral B
AD  - Department of Hematopathology, UT MD Anderson Cancer Center, Houston, TX, USA.
FAU - Kadia, Tapan
AU  - Kadia T
AD  - Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX, USA.
FAU - Konopleva, Marina
AU  - Konopleva M
AUID- ORCID: 0000-0002-9347-2212
AD  - Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX, USA.
FAU - Jabbour, Elias
AU  - Jabbour E
AD  - Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX, USA.
FAU - Jain, Nitin
AU  - Jain N
AUID- ORCID: 0000-0003-0114-8384
AD  - Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX, USA.
LA  - eng
GR  - P01 CA049639/CA/NCI NIH HHS/United States
GR  - P30 CA016672/CA/NCI NIH HHS/United States
PT  - Case Reports
DEP - 20170918
PL  - United States
TA  - Case Rep Hematol
JT  - Case reports in hematology
JID - 101576456
PMC - PMC5624137
EDAT- 2017/10/28 06:00
MHDA- 2017/10/28 06:01
PMCR- 2017/09/18
CRDT- 2017/10/28 06:00
PHST- 2017/05/28 00:00 [received]
PHST- 2017/08/08 00:00 [accepted]
PHST- 2017/10/28 06:00 [entrez]
PHST- 2017/10/28 06:00 [pubmed]
PHST- 2017/10/28 06:01 [medline]
PHST- 2017/09/18 00:00 [pmc-release]
AID - 10.1155/2017/2413587 [doi]
PST - ppublish
SO  - Case Rep Hematol. 2017;2017:2413587. doi: 10.1155/2017/2413587. Epub 2017 Sep 18.