PMID- 29075648
OWN - NLM
STAT- MEDLINE
DCOM- 20180718
LR  - 20181113
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2017
DP  - 2017
TI  - Dendritic Cells in Sepsis: Pathological Alterations and Therapeutic Implications.
PG  - 3591248
LID - 10.1155/2017/3591248 [doi]
LID - 3591248
AB  - Sepsis is the leading cause of death for critically ill patients in recent years. 
      Dendritic cells (DCs) are important antigen-presenting cells and play a key role 
      in immune response by regulating the innate and adaptive immunity. The number of 
      DCs, the differentiation of monocytes into DCs, and the levels of surface 
      molecules associated with the function of DCs are changed in the development of 
      sepsis. There are many mechanisms involved in the alterations of DCs during 
      sepsis, including the induction of apoptosis, reactive oxygen species generation, 
      activation of the Wnt signaling pathway, epigenetic regulation, and variation in 
      Toll-like receptor-dependent signaling. In this review, we present the 
      classifications of DC subsets and mechanisms involved in the alterations of DCs 
      in sepsis, as well as further discuss the therapeutic strategies targeting DCs in 
      sepsis to improve the aberrant immune response and prolong the life during sepsis 
      progression.
FAU - Wu, Dong-Dong
AU  - Wu DD
AUID- ORCID: 0000-0001-6739-8437
AD  - School of Medical Sciences, College of Medicine, Henan University, Kaifeng, Henan 
      475004, China.
AD  - Institute of Environmental Medicine, Henan University, Kaifeng, Henan 475004, 
      China.
FAU - Li, Tao
AU  - Li T
AD  - School of Medical Sciences, College of Medicine, Henan University, Kaifeng, Henan 
      475004, China.
FAU - Ji, Xin-Ying
AU  - Ji XY
AUID- ORCID: 0000-0003-0690-4206
AD  - School of Medical Sciences, College of Medicine, Henan University, Kaifeng, Henan 
      475004, China.
AD  - The Affiliated Nanshi Hospital of Henan University, Nanyang, Henan 473000, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170918
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - Antigen Presentation
MH  - Apoptosis
MH  - Dendritic Cells/*immunology
MH  - Epigenesis, Genetic
MH  - Humans
MH  - Immunity, Innate
MH  - Immunotherapy/*methods
MH  - Sepsis/*immunology/therapy
MH  - Toll-Like Receptors/metabolism
MH  - Wnt Signaling Pathway
PMC - PMC5624156
EDAT- 2017/10/28 06:00
MHDA- 2018/07/19 06:00
PMCR- 2017/09/18
CRDT- 2017/10/28 06:00
PHST- 2017/04/08 00:00 [received]
PHST- 2017/07/24 00:00 [revised]
PHST- 2017/08/08 00:00 [accepted]
PHST- 2017/10/28 06:00 [entrez]
PHST- 2017/10/28 06:00 [pubmed]
PHST- 2018/07/19 06:00 [medline]
PHST- 2017/09/18 00:00 [pmc-release]
AID - 10.1155/2017/3591248 [doi]
PST - ppublish
SO  - J Immunol Res. 2017;2017:3591248. doi: 10.1155/2017/3591248. Epub 2017 Sep 18.