PMID- 29076309
OWN - NLM
STAT- MEDLINE
DCOM- 20180702
LR  - 20240327
IS  - 1560-2281 (Electronic)
IS  - 1083-3668 (Print)
IS  - 1083-3668 (Linking)
VI  - 22
IP  - 10
DP  - 2017 Oct
TI  - Optimization of dual-wavelength intravascular photoacoustic imaging of 
      atherosclerotic plaques using Monte Carlo optical modeling.
PG  - 1-12
LID - 10.1117/1.JBO.22.10.106012 [doi]
LID - 106012
AB  - Coronary heart disease (the presence of coronary atherosclerotic plaques) is a 
      significant health problem in the industrialized world. A clinical method to 
      accurately visualize and characterize atherosclerotic plaques is needed. 
      Intravascular photoacoustic (IVPA) imaging is being developed to fill this role, 
      but questions remain regarding optimal imaging wavelengths. We utilized a Monte 
      Carlo optical model to simulate IVPA excitation in coronary tissues, identifying 
      optimal wavelengths for plaque characterization. Near-infrared wavelengths 
      (</=1800  nm) were simulated, and single- and dual-wavelength data were analyzed 
      for accuracy of plaque characterization. Results indicate light penetration is 
      best in the range of 1050 to 1370 nm, where 5% residual fluence can be achieved 
      at clinically relevant depths of >/=2  mm in arteries. Across the arterial wall, 
      fluence may vary by over 10-fold, confounding plaque characterization. For 
      single-wavelength results, plaque segmentation accuracy peaked at 1210 and 
      1720 nm, though correlation was poor (<0.13). Dual-wavelength analysis proved 
      promising, with 1210 nm as the most successful primary wavelength ( approximately 1.0). Results 
      suggest that, without flushing the luminal blood, a primary and secondary 
      wavelength near 1210 and 1350 nm, respectively, may offer the best implementation 
      of dual-wavelength IVPA imaging. These findings could guide the development of a 
      cost-effective clinical system by highlighting optimal wavelengths and improving 
      plaque characterization.
CI  - (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).
FAU - Dana, Nicholas
AU  - Dana N
AD  - University of Texas at Austin, Department of Biomedical Engineering, Austin, 
      Texas, United States.
FAU - Sowers, Timothy
AU  - Sowers T
AD  - Georgia Institute of Technology, Parker H. Petit Institute for Bioengineering and 
      Bioscience, Atlant, United States.
AD  - Georgia Institute of Technology, George W. Woodruff School of Mechanical 
      Engineering, Atlanta, Georg, United States.
FAU - Karpiouk, Andrei
AU  - Karpiouk A
AD  - Georgia Institute of Technology, School of Electrical and Computer Engineering, 
      Atlanta, Georgia, United States.
FAU - Vanderlaan, Donald
AU  - Vanderlaan D
AD  - Georgia Institute of Technology, School of Electrical and Computer Engineering, 
      Atlanta, Georgia, United States.
FAU - Emelianov, Stanislav
AU  - Emelianov S
AD  - Georgia Institute of Technology, School of Electrical and Computer Engineering, 
      Atlanta, Georgia, United States.
AD  - Emory University School of Medicine, Georgia Institute of Technology, Wallace H. 
      Coulter Department, United States.
LA  - eng
GR  - R01 HL124417/HL/NHLBI NIH HHS/United States
GR  - T32 EB007507/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Biomed Opt
JT  - Journal of biomedical optics
JID - 9605853
SB  - IM
MH  - Atherosclerosis/*diagnostic imaging
MH  - Humans
MH  - Monte Carlo Method
MH  - *Photoacoustic Techniques
MH  - Plaque, Atherosclerotic/*diagnostic imaging
MH  - Spectrum Analysis
PMC - PMC5658287
OTO - NOTNLM
OT  - Monte Carlo
OT  - atherosclerosis
OT  - clinical
OT  - intravascular
OT  - photoacoustic
OT  - spectroscopic
EDAT- 2017/10/28 06:00
MHDA- 2018/07/03 06:00
PMCR- 2018/10/27
CRDT- 2017/10/28 06:00
PHST- 2017/07/21 00:00 [received]
PHST- 2017/09/28 00:00 [accepted]
PHST- 2017/10/28 06:00 [entrez]
PHST- 2017/10/28 06:00 [pubmed]
PHST- 2018/07/03 06:00 [medline]
PHST- 2018/10/27 00:00 [pmc-release]
AID - JBO-170468R [pii]
AID - 170468R [pii]
AID - 10.1117/1.JBO.22.10.106012 [doi]
PST - ppublish
SO  - J Biomed Opt. 2017 Oct;22(10):1-12. doi: 10.1117/1.JBO.22.10.106012.