PMID- 29076602
OWN - NLM
STAT- MEDLINE
DCOM- 20190516
LR  - 20190516
IS  - 1531-8257 (Electronic)
IS  - 0885-3185 (Linking)
VI  - 33
IP  - 2
DP  - 2018 Feb
TI  - Diffusion tensor imaging marks dopaminergic and serotonergic lesions in the 
      Parkinsonian monkey.
PG  - 298-309
LID - 10.1002/mds.27201 [doi]
AB  - BACKGROUND: Diffusion tensor imaging has received major interest to highlight 
      markers of neurodegeneration in Parkinson's disease. Whether the alteration of 
      diffusion parameters mostly depicts dopaminergic lesions or can also reveal 
      serotonergic denervation remains a question. OBJECTIVES: The aim of this study 
      was to determine the best diffusion tensor imaging markers of 
      1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 
      3,4-methylene-dioxy-methamphetamine (MDMA; also known as ecstasy) lesions in the 
      nonhuman primate. METHODS: We acquired measures of mean diffusivity and 
      fractional anisotropy longitudinally (before and after MPTP and MDMA) and 
      correlated them with severity of parkinsonism, PET imaging, and postmortem fiber 
      quantification. RESULTS: MPTP-induced lesions were associated with increases of 
      mean diffusivity within both the caudate nucleus and the anterior cingulate 
      cortex, whereas MDMA-induced lesions caused an increase of fractional anisotropy 
      within the caudate nucleus. These variations of diffusion tensor imaging 
      correlated with the motor score. CONCLUSION: Taken together, these results 
      demonstrate that diffusion measures within specific brain regions can mark 
      severity of dopaminergic and serotonergic induced lesions in a neurotoxic 
      nonhuman primate model of Parkinson's disease. (c) 2017 International Parkinson and 
      Movement Disorder Society.
CI  - (c) 2017 International Parkinson and Movement Disorder Society.
FAU - Metereau, Elise
AU  - Metereau E
AD  - Universite de Lyon, Centre National de la Recherche Scientifique, Institut des 
      Sciences Cognitives Marc Jeannerod, Bron, France.
FAU - Beaudoin-Gobert, Maude
AU  - Beaudoin-Gobert M
AD  - Universite de Lyon, Centre National de la Recherche Scientifique, Institut des 
      Sciences Cognitives Marc Jeannerod, Bron, France.
FAU - Duperrier, Sandra
AU  - Duperrier S
AD  - Universite de Lyon, Centre National de la Recherche Scientifique, Institut des 
      Sciences Cognitives Marc Jeannerod, Bron, France.
FAU - Thobois, Stephane
AU  - Thobois S
AD  - Universite de Lyon, Centre National de la Recherche Scientifique, Institut des 
      Sciences Cognitives Marc Jeannerod, Bron, France.
AD  - Hospices Civils de Lyon, Hopital Neurologique Pierre Wertheimer, Lyon, France.
FAU - Tremblay, Leon
AU  - Tremblay L
AD  - Universite de Lyon, Centre National de la Recherche Scientifique, Institut des 
      Sciences Cognitives Marc Jeannerod, Bron, France.
FAU - Sgambato-Faure, Veronique
AU  - Sgambato-Faure V
AUID- ORCID: 0000-0002-8792-8586
AD  - Universite de Lyon, Centre National de la Recherche Scientifique, Institut des 
      Sciences Cognitives Marc Jeannerod, Bron, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171027
PL  - United States
TA  - Mov Disord
JT  - Movement disorders : official journal of the Movement Disorder Society
JID - 8610688
RN  - 0 (Dopamine Agents)
RN  - 0 (Serotonin Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - 9P21XSP91P (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
MH  - Animals
MH  - Brain/diagnostic imaging/drug effects/*metabolism
MH  - *Diffusion Tensor Imaging
MH  - Disease Models, Animal
MH  - Dopamine/*metabolism
MH  - Dopamine Agents/toxicity
MH  - Macaca fascicularis
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/toxicity
MH  - Parkinsonian Disorders/chemically induced/*diagnostic imaging/*metabolism
MH  - Serotonin/*metabolism
MH  - Serotonin Agents/toxicity
MH  - Statistics, Nonparametric
MH  - Time Factors
MH  - Tyrosine 3-Monooxygenase/metabolism
OTO - NOTNLM
OT  - Parkinson's disease
OT  - diffusion tensor imaging
OT  - dopamine
OT  - monkey
OT  - serotonin
EDAT- 2017/10/28 06:00
MHDA- 2019/05/17 06:00
CRDT- 2017/10/28 06:00
PHST- 2017/06/02 00:00 [received]
PHST- 2017/08/24 00:00 [revised]
PHST- 2017/08/27 00:00 [accepted]
PHST- 2017/10/28 06:00 [pubmed]
PHST- 2019/05/17 06:00 [medline]
PHST- 2017/10/28 06:00 [entrez]
AID - 10.1002/mds.27201 [doi]
PST - ppublish
SO  - Mov Disord. 2018 Feb;33(2):298-309. doi: 10.1002/mds.27201. Epub 2017 Oct 27.