PMID- 29077002
OWN - NLM
STAT- MEDLINE
DCOM- 20180614
LR  - 20211204
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 9
IP  - 11
DP  - 2017 Oct 27
TI  - The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling.
LID - 10.3390/nu9111176 [doi]
LID - 1176
AB  - The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that 
      controls a wide spectrum of cellular processes, including cell growth, 
      differentiation, and metabolism. mTOR forms two distinct multiprotein complexes 
      known as mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), which are 
      characterized by the presence of raptor and rictor, respectively. mTOR controls 
      insulin signaling by regulating several downstream components such as growth 
      factor receptor-bound protein 10 (Grb10), insulin receptor substrate (IRS-1), 
      F-box/WD repeat-containing protein 8 (Fbw8), and insulin like growth factor 1 
      receptor/insulin receptor (IGF-IR/IR). In addition, mTORC1 and mTORC2 regulate 
      each other through a feedback loop to control cell growth. This review outlines 
      the current understanding of mTOR regulation in insulin signaling in the context 
      of whole body metabolism.
FAU - Yoon, Mee-Sup
AU  - Yoon MS
AD  - Department of Molecular Medicine, School of Medicine, Gachon University, Incheon 
      21999, Korea. msyoon@gachon.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171027
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (F-Box Proteins)
RN  - 0 (FBXW8 protein, human)
RN  - 0 (IRS1 protein, human)
RN  - 0 (Insulin)
RN  - 0 (Insulin Receptor Substrate Proteins)
RN  - 0 (Rapamycin-Insensitive Companion of mTOR Protein)
RN  - 0 (Regulatory-Associated Protein of mTOR)
RN  - 151441-47-3 (GRB10 Adaptor Protein)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
RN  - EC 2.7.10.1 (Receptor, Insulin)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 2)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Cell Proliferation
MH  - F-Box Proteins/metabolism
MH  - GRB10 Adaptor Protein/metabolism
MH  - Humans
MH  - Insulin/*metabolism
MH  - Insulin Receptor Substrate Proteins/metabolism
MH  - Mechanistic Target of Rapamycin Complex 1/*metabolism
MH  - Mechanistic Target of Rapamycin Complex 2/*metabolism
MH  - Rapamycin-Insensitive Companion of mTOR Protein/metabolism
MH  - Receptor, IGF Type 1/metabolism
MH  - Receptor, Insulin/metabolism
MH  - Regulatory-Associated Protein of mTOR/metabolism
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC5707648
OTO - NOTNLM
OT  - insulin
OT  - mTOR complex1 (mTORC1)
OT  - mTOR complex2 (mTORC2)
OT  - mammalian target of rapamycin (mTOR)
OT  - protein kinase B (PKB/Akt)
COIS- The author declares no conflicts of interest.
EDAT- 2017/10/28 06:00
MHDA- 2018/06/15 06:00
PMCR- 2017/11/01
CRDT- 2017/10/28 06:00
PHST- 2017/09/21 00:00 [received]
PHST- 2017/10/23 00:00 [revised]
PHST- 2017/10/24 00:00 [accepted]
PHST- 2017/10/28 06:00 [entrez]
PHST- 2017/10/28 06:00 [pubmed]
PHST- 2018/06/15 06:00 [medline]
PHST- 2017/11/01 00:00 [pmc-release]
AID - nu9111176 [pii]
AID - nutrients-09-01176 [pii]
AID - 10.3390/nu9111176 [doi]
PST - epublish
SO  - Nutrients. 2017 Oct 27;9(11):1176. doi: 10.3390/nu9111176.