PMID- 29077651
OWN - NLM
STAT- MEDLINE
DCOM- 20171106
LR  - 20190210
IS  - 1539-736X (Electronic)
IS  - 0022-3018 (Print)
IS  - 0022-3018 (Linking)
VI  - 205
IP  - 11
DP  - 2017 Nov
TI  - Exploring the Relationship Between Body Mass Index and Positive Symptom Severity 
      in Persons at Clinical High Risk for Psychosis.
PG  - 893-895
LID - 10.1097/NMD.0000000000000736 [doi]
AB  - Metabolic health and positive symptom severity has been investigated in 
      schizophrenia, but not in clinical high risk (CHR) patients. We hypothesized that 
      greater body mass index (BMI) in CHR patients would be related to less positive 
      symptoms. We examined this relationship in CHR patients being treated with 1) no 
      psychotropic medications (n = 58), 2) an antipsychotic (n = 14), or 3) an 
      antidepressant without an antipsychotic (n = 10). We found no relationship 
      between BMI and positive symptoms in unmedicated CHR patients, the majority of 
      whom had a narrow BMI range between 20 and 30. However, in the smaller sample of 
      CHR patients taking an antidepressant or antipsychotic, BMI was negatively 
      correlated with positive symptoms. Although potentially underpowered, these 
      preliminary findings provide initial steps in elucidating the relationships 
      between metabolic health, neurochemistry, and symptom severity in CHR patients.
FAU - Caravaggio, Fernando
AU  - Caravaggio F
AD  - *Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; and 
      daggerDepartment of Psychiatry and Radiology, and double daggerThe Center of Prevention & 
      Evaluation, Columbia University College of Physicians and Surgeons, and the New 
      York State Psychiatric Institute, New York, New York.
FAU - Brucato, Gary
AU  - Brucato G
FAU - Kegeles, Lawrence S
AU  - Kegeles LS
FAU - Lehembre-Shiah, Eugenie
AU  - Lehembre-Shiah E
FAU - Arndt, Leigh Y
AU  - Arndt LY
FAU - Colibazzi, Tiziano
AU  - Colibazzi T
FAU - Girgis, Ragy
AU  - Girgis R
LA  - eng
GR  - K23 MH106746/MH/NIMH NIH HHS/United States
GR  - R01 MH093398/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Nerv Ment Dis
JT  - The Journal of nervous and mental disease
JID - 0375402
RN  - 0 (Antidepressive Agents)
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antidepressive Agents/therapeutic use
MH  - Antipsychotic Agents/therapeutic use
MH  - *Body Mass Index
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/drug therapy/etiology/*psychology
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Young Adult
PMC - PMC5678950
MID - NIHMS895451
EDAT- 2017/10/28 06:00
MHDA- 2017/11/07 06:00
PMCR- 2018/11/01
CRDT- 2017/10/28 06:00
PHST- 2017/10/28 06:00 [entrez]
PHST- 2017/10/28 06:00 [pubmed]
PHST- 2017/11/07 06:00 [medline]
PHST- 2018/11/01 00:00 [pmc-release]
AID - 00005053-201711000-00010 [pii]
AID - 10.1097/NMD.0000000000000736 [doi]
PST - ppublish
SO  - J Nerv Ment Dis. 2017 Nov;205(11):893-895. doi: 10.1097/NMD.0000000000000736.