PMID- 29078742
OWN - NLM
STAT- MEDLINE
DCOM- 20181012
LR  - 20181012
IS  - 1945-5119 (Electronic)
IS  - 1074-9357 (Linking)
VI  - 25
IP  - 1
DP  - 2018 Jan
TI  - A single session of moderate intensity walking increases brain-derived 
      neurotrophic factor (BDNF) in the chronic post-stroke patients.
PG  - 1-5
LID - 10.1080/10749357.2017.1373500 [doi]
AB  - Background Aerobic exercise, even for short durations, may promote an increase in 
      serum concentrations of brain-derived neurotrophic factor (BDNF). However, it is 
      necessary to determine the optimal exercise types and intensities to increase 
      BDNF levels. Objectives This aim of this study was investigate the effects of 
      mild and moderate intensity acute aerobic exercise on serum BDNF levels in 
      patients in the chronic post-stroke phase. Methods The participants answered a 
      socio-demographic questionnaire, cognitive assessment (Mini Mental State 
      Examination), assessment of depressive symptoms (Hamilton Depression Scale), 
      fatigue (Fatigue Severity Scale) and functional capacity (6-minute walk test). 
      Blood samples were collected before and after each session. The measurement of 
      the concentration of BDNF was performed using the enzyme-linked immunosorbent 
      assay . Patients were asked to walk for 30-min in the target training zone (mild 
      intensity, 50-63% of maximum heart rate, and moderate intensity, 64-76% of 
      maximum heart rate), once each week for 2 consecutive weeks. Results Our results 
      indicate that 30 min of acute aerobic exercise at a moderate intensity, but not 
      at a mild intensity, increases serum BDNF levels in the chronic post-stroke 
      phase. Conclusions This study suggests a potential mechanism for the beneficial 
      effects of exercise as a component of recovery from stroke, and provides the 
      basis for future studies that will elucidate the specific parameters for clinical 
      applications.
FAU - Morais, Viviane Aparecida Carvalho de
AU  - Morais VAC
AD  - a Laboratorio de Neurobiologia, Departamento de Morfologia , Instituto de 
      Ciencias Biologicas, Universidade Federal de Minas Gerais (UFMG) , Belo Horizonte 
      , Brazil.
FAU - Tourino, Marina Ferreira da Silva
AU  - Tourino MFDS
AD  - a Laboratorio de Neurobiologia, Departamento de Morfologia , Instituto de 
      Ciencias Biologicas, Universidade Federal de Minas Gerais (UFMG) , Belo Horizonte 
      , Brazil.
FAU - Almeida, Ana Carolina de Souza
AU  - Almeida ACS
AUID- ORCID: 0000-0002-3531-8647
AD  - a Laboratorio de Neurobiologia, Departamento de Morfologia , Instituto de 
      Ciencias Biologicas, Universidade Federal de Minas Gerais (UFMG) , Belo Horizonte 
      , Brazil.
FAU - Albuquerque, Thais Bueno Dias
AU  - Albuquerque TBD
AD  - a Laboratorio de Neurobiologia, Departamento de Morfologia , Instituto de 
      Ciencias Biologicas, Universidade Federal de Minas Gerais (UFMG) , Belo Horizonte 
      , Brazil.
FAU - Linhares, Roberta Castro
AU  - Linhares RC
AD  - a Laboratorio de Neurobiologia, Departamento de Morfologia , Instituto de 
      Ciencias Biologicas, Universidade Federal de Minas Gerais (UFMG) , Belo Horizonte 
      , Brazil.
FAU - Christo, Paulo Pereira
AU  - Christo PP
AD  - b Ambulatorio de Neurologia , Centro de Especialidades Medicas da Santa Casa de 
      Belo Horizonte , Belo Horizonte , Brazil.
FAU - Martinelli, Patricia Massara
AU  - Martinelli PM
AD  - a Laboratorio de Neurobiologia, Departamento de Morfologia , Instituto de 
      Ciencias Biologicas, Universidade Federal de Minas Gerais (UFMG) , Belo Horizonte 
      , Brazil.
FAU - Scalzo, Paula Luciana
AU  - Scalzo PL
AUID- ORCID: 0000-0003-1383-8550
AD  - a Laboratorio de Neurobiologia, Departamento de Morfologia , Instituto de 
      Ciencias Biologicas, Universidade Federal de Minas Gerais (UFMG) , Belo Horizonte 
      , Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171027
PL  - England
TA  - Top Stroke Rehabil
JT  - Topics in stroke rehabilitation
JID - 9439750
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Chronic Disease
MH  - Cognition Disorders/etiology
MH  - Exercise
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Stroke/*blood/complications
MH  - Walking/*physiology
OTO - NOTNLM
OT  - Stroke
OT  - aerobic exercise
OT  - brain-derived neurotrophic factor
OT  - neuroplasticity
OT  - rehabilitation
EDAT- 2017/10/29 06:00
MHDA- 2018/10/13 06:00
CRDT- 2017/10/29 06:00
PHST- 2017/10/29 06:00 [pubmed]
PHST- 2018/10/13 06:00 [medline]
PHST- 2017/10/29 06:00 [entrez]
AID - 10.1080/10749357.2017.1373500 [doi]
PST - ppublish
SO  - Top Stroke Rehabil. 2018 Jan;25(1):1-5. doi: 10.1080/10749357.2017.1373500. Epub 
      2017 Oct 27.