PMID- 2907960
OWN - NLM
STAT- MEDLINE
DCOM- 19890629
LR  - 20131121
IS  - 0231-424X (Print)
IS  - 0231-424X (Linking)
VI  - 72
IP  - 3-4
DP  - 1988
TI  - The effects of different receptor blockers on the 
      H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH induced inhibition of extinction of active 
      avoidance behaviour.
PG  - 315-20
AB  - H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH after intracerebroventricular (icv.) 
      administration inhibited the extinction of active avoidance behaviour for a short 
      period. The dopamine receptor blocker haloperidol completely blocked this effect 
      of the heptapeptide, while the muscarinic anticholinergic agent atropine only 
      partly inhibited it. The alpha 1-receptor blocker phenoxybenzamine and the 
      beta-receptor blocker propranolol did not significantly influence the extinction 
      inhibition induced by the peptide. These results suggest that the dopaminergic 
      and, in part the cholinergic system, play important roles in this behavioural 
      action of H-Phe-Ile-Tyr-Ser-Tyr-Lys-OH.
FAU - Telegdy, G
AU  - Telegdy G
AD  - Department of Pathophysiology, University Medical School, Szeged, Hungary.
FAU - Vecsei, L
AU  - Vecsei L
FAU - Schally, A V
AU  - Schally AV
LA  - eng
PT  - Journal Article
PL  - Hungary
TA  - Acta Physiol Hung
JT  - Acta physiologica Hungarica
JID - 8309201
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Oligopeptides)
RN  - 0 (Receptors, Adrenergic)
RN  - 0 (Receptors, Cholinergic)
RN  - 78107-95-6 (H-phenylalanyl-isoleucyl-tyrosyl-histidyl-seryl-tyrosyl-lysine)
RN  - 7C0697DR9I (Atropine)
RN  - J6292F8L3D (Haloperidol)
SB  - IM
MH  - Adrenergic alpha-Antagonists/pharmacokinetics
MH  - Adrenergic beta-Antagonists/pharmacokinetics
MH  - Animals
MH  - Atropine/pharmacokinetics
MH  - Avoidance Learning/*drug effects
MH  - Escape Reaction/*drug effects
MH  - Extinction, Psychological/*drug effects
MH  - Haloperidol/pharmacokinetics
MH  - Injections, Intraventricular
MH  - Male
MH  - Oligopeptides/administration & dosage/antagonists & inhibitors/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Adrenergic/*drug effects
MH  - Receptors, Cholinergic/*drug effects
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
PST - ppublish
SO  - Acta Physiol Hung. 1988;72(3-4):315-20.