PMID- 29080083
OWN - NLM
STAT- MEDLINE
DCOM- 20190131
LR  - 20220408
IS  - 1573-7365 (Electronic)
IS  - 0885-7490 (Linking)
VI  - 33
IP  - 1
DP  - 2018 Feb
TI  - Evaluation of metformin effects in the chronic phase of spontaneous seizures in 
      pilocarpine model of temporal lobe epilepsy.
PG  - 107-114
LID - 10.1007/s11011-017-0132-z [doi]
AB  - Temporal lobe epilepsy (TLE) is a common form of drug-resistant epilepsy that 
      sometimes responds to dietary manipulation such as the 'ketogenic diet'. Here we 
      have investigated the effects of metformin in the rat pilocaroin model of TLE. 
      Male rats were treated with intra peritoneal injection of pilocarpine 
      hydrochloride, in dose of 360 mg/kg to induce status epilepticus (SE). At 45 day 
      after induction of SE, metformin was injected intraperitoneally in dose of 
      250 mg/kg/day for 5 days. We show that metformin potently reduces the progression 
      of seizures and blocks seizure-induced over-expression of brain-derived 
      neurotropic factor (BDNF) and its receptor, Tropomyosin receptor kinase B (TrkB). 
      We have shown that this reduced expression pattern is mediated by the 
      transcriptional co-repressor CtBP (C-terminal binding protein). Moreover, 
      metformin decreased mechanistic target of rapamycin (mTOR) activation through 
      activation of AMP-activated protein kinase (AMPK) signaling pathway. Our findings 
      have been shown that metformin has anticonvulsant and antiepileptic properties, 
      and suggesting that antiglycolytic compounds such as metformin may represent a 
      new class of drugs for treating epilepsy.
FAU - Mehrabi, Soraya
AU  - Mehrabi S
AD  - Cellular and Molecular Research Center, Iran University of Medical Science, 
      Tehran, Iran.
FAU - Sanadgol, Nima
AU  - Sanadgol N
AD  - Department of Biology, Faculty of Sciences, University of Zabol, Zabol, Iran.
AD  - Young Researchers and Elite Club, Zahedan Branch, Islamic Azad University, 
      Zahedan, Iran.
FAU - Barati, Mahmood
AU  - Barati M
AD  - Department of Biotechnology, Faculty of Allied Medicine, Iran University of 
      Medical Science, Tehran, Iran.
FAU - Shahbazi, Ali
AU  - Shahbazi A
AD  - Faculty of Advanced Technologies in Medicine, Department of Neuroscience, Iran 
      University of Medical Sciences, Tehran, Iran.
FAU - Vahabzadeh, Gelareh
AU  - Vahabzadeh G
AD  - Cellular and Molecular Research Center, Iran University of Medical Science, 
      Tehran, Iran.
AD  - Department of Pharmacology, Iran University of Medical Sciences, Tehran, Iran.
FAU - Barzroudi, Mitra
AU  - Barzroudi M
AD  - Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran.
FAU - Seifi, Morteza
AU  - Seifi M
AD  - Department of Medical Genetics, Faculty of Medicine and Dentistry, University of 
      Alberta, Edmonton, AB, Canada.
FAU - Gholipourmalekabadi, Mazaher
AU  - Gholipourmalekabadi M
AD  - Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced 
      Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
FAU - Golab, Fereshteh
AU  - Golab F
AD  - Cellular and Molecular Research Center, Iran University of Medical Science, 
      Tehran, Iran. fgolab520@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171027
PL  - United States
TA  - Metab Brain Dis
JT  - Metabolic brain disease
JID - 8610370
RN  - 0 (Anticonvulsants)
RN  - 01MI4Q9DI3 (Pilocarpine)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Animals
MH  - Anticonvulsants/*pharmacology
MH  - Disease Models, Animal
MH  - Epilepsy, Temporal Lobe/*drug therapy
MH  - Male
MH  - Metformin/*pharmacology
MH  - Pilocarpine/pharmacology
MH  - Rats, Wistar
MH  - Seizures/chemically induced/*drug therapy
OTO - NOTNLM
OT  - Metformin
OT  - Pilocarpine
OT  - Spontaneous seizures
OT  - Temporal lobe epilepsy
EDAT- 2017/10/29 06:00
MHDA- 2019/02/01 06:00
CRDT- 2017/10/29 06:00
PHST- 2017/07/15 00:00 [received]
PHST- 2017/10/09 00:00 [accepted]
PHST- 2017/10/29 06:00 [pubmed]
PHST- 2019/02/01 06:00 [medline]
PHST- 2017/10/29 06:00 [entrez]
AID - 10.1007/s11011-017-0132-z [pii]
AID - 10.1007/s11011-017-0132-z [doi]
PST - ppublish
SO  - Metab Brain Dis. 2018 Feb;33(1):107-114. doi: 10.1007/s11011-017-0132-z. Epub 
      2017 Oct 27.