PMID- 2908064
OWN - NLM
STAT- MEDLINE
DCOM- 19890808
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 31
IP  - 1
DP  - 1988 Sep
TI  - Advantages and disadvantages of a rapid method to train drug discrimination.
PG  - 239-42
AB  - In an effort to reduce the often extensive period of time needed to train rats to 
      discriminate between a drugged and nondrugged state, a fast training regimen was 
      employed with 1.5 mg/kg 3,4-methylenedioxymethamphetamine (MDMA) used as the 
      training drug in ten rats. This protocol consisted of one to three training 
      sessions per day and it was compared to the more conventional method of 
      once-per-day training in an equal number of rats. Results indicate that the 
      fast-trained rats learned the discrimination in significantly fewer sessions than 
      the slowly-trained rats. However, the subsequent dose-response experiments 
      indicate that when the fast-trained rats are tested with various doses of MDMA, 
      without prior vehicle treatment, their sensitivity to the drug is less than that 
      of the slowly-trained rats. When a vehicle session is presented prior to drug 
      dose-response testing, both groups perform similarly. It appears that the 
      preceding vehicle sessions function as a reference point for the fast-trained 
      rats and, although the more rapid training regimen allows for faster learning, 
      these treatment regimens should be employed with caution when subsequent 
      dose-response tests and generalization tests with other drugs are conducted.
FAU - Schechter, M D
AU  - Schechter MD
AD  - Department of Pharmacology, Northeastern Ohio Universities College of Medicine, 
      Rootstown 44272.
LA  - eng
GR  - NIDA 04181/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Amphetamines)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Discrimination Learning/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Drug Tolerance
MH  - Male
MH  - Methods
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
EDAT- 1988/09/01 00:00
MHDA- 1988/09/01 00:01
CRDT- 1988/09/01 00:00
PHST- 1988/09/01 00:00 [pubmed]
PHST- 1988/09/01 00:01 [medline]
PHST- 1988/09/01 00:00 [entrez]
AID - 0091-3057(88)90340-1 [pii]
AID - 10.1016/0091-3057(88)90340-1 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1988 Sep;31(1):239-42. doi: 
      10.1016/0091-3057(88)90340-1.