PMID- 29080981
OWN - NLM
STAT- MEDLINE
DCOM- 20180209
LR  - 20181202
IS  - 1539-0829 (Electronic)
IS  - 1534-4827 (Linking)
VI  - 17
IP  - 12
DP  - 2017 Oct 28
TI  - Genetic Risk Scores for Type 1 Diabetes Prediction and Diagnosis.
PG  - 129
LID - 10.1007/s11892-017-0961-5 [doi]
AB  - PURPOSE OF REVIEW: About 50% of the heritability of type 1 diabetes (T1D) is 
      attributed to human leukocyte antigen (HLA) alleles and the remainder to several 
      (close to 50) non-HLA loci. A current challenge in the field of the genetics of 
      T1D is to apply the knowledge accumulated in the last 40 years towards 
      differential diagnosis and risk assessment. RECENT FINDINGS: T1D genetic risk 
      scores seek to combine the information from HLA and non-HLA alleles to improve 
      the accuracy of diagnosis, prediction, and prognosis. Here, we describe genetic 
      risk scores that have been developed and validated in various settings and 
      populations. Several genetic scores have been proposed that merge disease risk 
      information from multiple genetic factors to optimize the use of genetic 
      information and ultimately improve prediction and diagnosis of T1D.
FAU - Redondo, Maria J
AU  - Redondo MJ
AD  - Texas Children's Hospital/Baylor College of Medicine, 6701 Fannin Street, CC1020, 
      Houston, TX, 77030, USA. redondo@bcm.edu.
FAU - Oram, Richard A
AU  - Oram RA
AD  - University of Exeter Medical School, Institute of Biomedical and Clinical 
      Science, RILD Building, Royal Devon and Exeter Hospital, Barrack Road, Exeter, 
      EX2 5DW, UK.
FAU - Steck, Andrea K
AU  - Steck AK
AD  - Barbara Davis Center for Childhood Diabetes, University of Colorado School of 
      Medicine, 1775 Aurora Ct, Aurora, CO, 80045, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171028
PL  - United States
TA  - Curr Diab Rep
JT  - Current diabetes reports
JID - 101093791
SB  - IM
MH  - Diabetes Mellitus, Type 1/*diagnosis/*genetics/immunology
MH  - Diabetes Mellitus, Type 2/genetics
MH  - *Genetic Predisposition to Disease
MH  - Genetic Testing
MH  - Humans
MH  - Risk Factors
OTO - NOTNLM
OT  - Genetic
OT  - HLA
OT  - Prediction
OT  - Risk
OT  - Score
OT  - Type 1 diabetes
EDAT- 2017/10/31 06:00
MHDA- 2018/02/10 06:00
CRDT- 2017/10/30 06:00
PHST- 2017/10/30 06:00 [entrez]
PHST- 2017/10/31 06:00 [pubmed]
PHST- 2018/02/10 06:00 [medline]
AID - 10.1007/s11892-017-0961-5 [pii]
AID - 10.1007/s11892-017-0961-5 [doi]
PST - epublish
SO  - Curr Diab Rep. 2017 Oct 28;17(12):129. doi: 10.1007/s11892-017-0961-5.