PMID- 29081148
OWN - NLM
STAT- MEDLINE
DCOM- 20180626
LR  - 20181202
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 97
IP  - 39
DP  - 2017 Oct 24
TI  - [Follow-up of resting-state brain function with magnetic resonance imaging in 
      patients with type 2 diabetes mellitus].
PG  - 3057-3061
LID - 10.3760/cma.j.issn.0376-2491.2017.39.004 [doi]
AB  - Objective: To investigate the changes of resting brain function with time in 
      patients with type 2 diabetes mellitus (T2DM) by using regional homogeneity 
      (ReHo) with resting-state functional magnetic resonance imaging (rs-fMRI). 
      Methods: Multidimensional cognitive function tests and rs-fMRI scans were 
      performed in 21 T2DM patients and 12 healthy controls in 2012 and 2015 
      respectively.The differences in clinical variables and the ReHo values before and 
      after were measured by paired sample t test, and the correlation between the 
      change of ReHo value and the change of clinical variables was measured by Pearson 
      correlation analysis based on voxel. Results: The delayed score (14+/-6) of the 
      T2DM patients in 2015 was significantly lower than that in 2012 (18+/-6) (t=-2.88, 
      P=0.009); while the value of ReHo in the bilateral occipital lobe and right 
      middle frontal gyrus was significantly lower than that in 2012 (P<0.01, Alphasim 
      correction). And the decreased ReHo value in the left occipital lobe was 
      significantly correlated with the change of complex figure test (CFT) delay score 
      and the trail making test-B (TMT-B)(r=0.52, -0.46, both P<0.05). No significant 
      change in cognitive function tests in the healthy control group was found between 
      the two years, ReHo value in right cuneus decreased significantly (P<0.01, 
      Alphasim correction), but it increased significantly in superior frontal gyrus 
      (P<0.01, Alphasim correction) in 2015.No significant correlation between the 
      changes of the ReHo values in the right cuneus and right superior frontal gyrus 
      and the changes of cognitive function scores was found in the healthy controls. 
      Conclusions: The visual memory is significantly declined in T2DM patients within 
      3 years.The reduced neural activity areas in T2DM patients are in the bilateral 
      occipitai lobes and the right middle frontal lobe. Decreased neural activity in 
      the left occipital area is related to visual impairment, information processing 
      speed and attention drops.
FAU - Qi, N
AU  - Qi N
AD  - Southeast University Medical College, Nanjing 210009, China.
FAU - Cui, Y
AU  - Cui Y
FAU - Liu, J C
AU  - Liu JC
FAU - Yu, M
AU  - Yu M
FAU - Teng, G J
AU  - Teng GJ
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Brain/diagnostic imaging/*physiopathology
MH  - *Brain Mapping
MH  - Cognition Disorders/etiology
MH  - Diabetes Mellitus, Type 2/complications/*physiopathology
MH  - Follow-Up Studies
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Memory Disorders/etiology
OTO - NOTNLM
OT  - Brain function
OT  - Diabetes mellitus, type 2
OT  - Functional magnetic resonance imaging
EDAT- 2017/10/31 06:00
MHDA- 2018/06/27 06:00
CRDT- 2017/10/31 06:00
PHST- 2017/10/31 06:00 [entrez]
PHST- 2017/10/31 06:00 [pubmed]
PHST- 2018/06/27 06:00 [medline]
AID - 10.3760/cma.j.issn.0376-2491.2017.39.004 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2017 Oct 24;97(39):3057-3061. doi: 
      10.3760/cma.j.issn.0376-2491.2017.39.004.