PMID- 29081188
OWN - NLM
STAT- MEDLINE
DCOM- 20190219
LR  - 20200717
IS  - 0253-2727 (Print)
IS  - 2707-9740 (Electronic)
IS  - 0253-2727 (Linking)
VI  - 38
IP  - 9
DP  - 2017 Sep 14
TI  - [Cytogenetic abnormalities and prognosis of 532 patients with multiple myeloma].
PG  - 739-743
LID - 10.3760/cma.j.issn.0253-2727.2017.09.002 [doi]
AB  - Objective: To explore the effect of 6 common cytogenetic abnormalities on the 
      prognosis of multiple myeloma (MM). Methods: Myeloma cells from a cohort of 532 
      newly-diagnosed MM patients enrolled were enriched by CD138 immunomagnetic beads, 
      then detected 13q-, 17p-, 1q+, t (4;14), t (11;14) and t (14;16) and other common 
      genetic abnormalities in MM by using interphase fluorescence in situ 
      hybridization (FISH) technique to compare the influence of different genetic 
      abnormalities on their prognoses. Results: The rate of cytogenetic abnormalities 
      was 78.20% (416/532) in 532 patients, of which 13q-accounted for 42.29% 
      (225/532), 17p-16.35% (87/532), 1q+ 53.38% (284/532), t (4;14) 25.94% (138/532), 
      t (11;14) 21.62% (115/532), t (14;16) 2.07% (11/532). Six kinds of cytogenetic 
      abnormalities were analyzed, 13q- and 17p-, 1q+, t (4; 14), t (14;16) were all 
      correlated (P <0.05). The univariate analysis indicated that 13q-, 1q+, t (4;14) 
      and t (14;16) had a significant effect on progression-free survival (PFS), 13q-, 
      17p-, t (4;14) and t (14;16) had a marked influence on overall survival (OS). The 
      multivariate analysis showed that 1q+, t (4;14) and t (14;16) were independent 
      adverse factors of PFS, 17p-, t (4;14) and t (14;16) were independent unfavorable 
      factors of OS. According to the independent prognosis factors number-based 
      groups, the median PFS with 0, 1, 2, 3 independent prognosis factors of patients 
      were 30.9, 28.4, 18.7 and 17.6 months (P =0.035) respectively, and the median OS 
      were 54.4, 46.1, 38.0 and 21.2 months (P =0.004) respectively. Conclusion: 1q+, 
      17p-, t (4;14) and t (14;16) were independent prognostic factors affecting the 
      survival of MM patients. 13q-is often accompanied by 17p-, 1q + and (or) t (4;14) 
      , simply 13q- was not an independent prognostic factor; the more number of 
      independent prognostic factors, the worse the prognosis of patients.
FAU - Wu, H
AU  - Wu H
AD  - Department of Hematology, Chang Zheng Hospital, The Second Military Medical 
      University, Shanghai 200003, China.
FAU - Zhang, H
AU  - Zhang H
FAU - He, H Y
AU  - He HY
FAU - Jiang, H
AU  - Jiang H
FAU - Zhao, Y Y
AU  - Zhao YY
FAU - An, R
AU  - An R
FAU - He, J
AU  - He J
FAU - Li, R
AU  - Li R
FAU - Lu, J
AU  - Lu J
FAU - Hou, J
AU  - Hou J
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
SB  - IM
MH  - Chromosome Aberrations
MH  - Chromosome Disorders
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Multiple Myeloma
MH  - Prognosis
PMC - PMC7348364
OTO - NOTNLM
OT  - Cytogenetics
OT  - Fluorescence in situ hybridization
OT  - Multiple, myeloma
OT  - Prognosis
EDAT- 2017/10/31 06:00
MHDA- 2019/03/21 06:00
PMCR- 2017/09/01
CRDT- 2017/10/31 06:00
PHST- 2017/10/31 06:00 [entrez]
PHST- 2017/10/31 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - cjh-38-09-739 [pii]
AID - 10.3760/cma.j.issn.0253-2727.2017.09.002 [doi]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2017 Sep 14;38(9):739-743. doi: 
      10.3760/cma.j.issn.0253-2727.2017.09.002.