PMID- 29081472
OWN - NLM
STAT- MEDLINE
DCOM- 20190603
LR  - 20190603
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 82
IP  - 3
DP  - 2018 Feb 23
TI  - Early Prediction Model for Successful Bridge to Recovery in Patients With 
      Fulminant Myocarditis Supported With Percutaneous Venoarterial Extracorporeal 
      Membrane Oxygenation　- Insights From the CHANGE PUMP Study.
PG  - 699-707
LID - 10.1253/circj.CJ-17-0549 [doi]
AB  - BACKGROUND: Cardiac recovery and prevention of end-organ damage are the 
      cornerstones of establishing successful bridge to recovery (BTR) in patients with 
      fulminant myocarditis (FM) supported with percutaneous venoarterial 
      extracorporeal membrane oxygenation (VA-ECMO). However, the timing and method of 
      successful BTR prediction still remain unclear. We aimed to develop a prediction 
      model for successful BTR in patients with FM supported with percutaneous 
      VA-ECMO.Methods and Results:This was a retrospective multicenter chart review 
      enrolling 99 patients (52+/-16 years; female, 42%) with FM treated with 
      percutaneous VA-ECMO. The S-group comprised patients who experienced percutaneous 
      VA-ECMO decannulation and subsequent discharge (n=46), and the F-group comprised 
      patients who either died in hospital or required conversion to other forms of 
      mechanical circulatory support (n=53). At VA-ECMO initiation (0-h), the S-group 
      had significantly higher left ventricular ejection fraction (LVEF) and lower 
      aspartate aminotransferase (AST) concentration than the F-group. At 48 h, the 
      LVEF, increase in the LVEF, and reduction of AST from 0-h were identified as 
      independent predictors in the S-group. Finally, we developed an S-group 
      prediction model comprising these 3 variables (area under the curve, 0.844; 95% 
      confidence interval, 0.745-0.944). CONCLUSIONS: We developed a model for use 48 h 
      after VA-ECMO initiation to predict successful BTR in patients with FM.
FAU - Sawamura, Akinori
AU  - Sawamura A
AD  - Department of Cardiology, Nagoya University Graduate School of Medicine.
FAU - Okumura, Takahiro
AU  - Okumura T
AD  - Department of Cardiology, Nagoya University Graduate School of Medicine.
FAU - Hirakawa, Akihiro
AU  - Hirakawa A
AD  - Department of Biostatistics and Bioinformatics, Graduate School of Medicine, The 
      University of Tokyo.
FAU - Ito, Masaaki
AU  - Ito M
AD  - Department of Cardiology and Nephrology, Mie University Graduate School of 
      Medicine.
FAU - Ozaki, Yukio
AU  - Ozaki Y
AD  - Department of Cardiology, Fujita Health University.
FAU - Ohte, Nobuyuki
AU  - Ohte N
AD  - Department of Cardio-Renal Medicine and Hypertension, Nagoya City University 
      Graduate School of Medical Sciences.
FAU - Amano, Tetsuya
AU  - Amano T
AD  - Department of Cardiology, Aichi Medical University Hospital.
FAU - Murohara, Toyoaki
AU  - Murohara T
AD  - Department of Cardiology, Nagoya University Graduate School of Medicine.
CN  - CHANGE PUMP Investigators
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20171027
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - Aspartate Aminotransferases/analysis
MH  - Extracorporeal Membrane Oxygenation/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocarditis/*diagnosis/therapy
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Retrospective Studies
MH  - Stroke Volume
OTO - NOTNLM
OT  - Bridge to recovery
OT  - Extracorporeal membrane oxygenation
OT  - Fulminant myocarditis
OT  - Mechanical circulatory support
OT  - Prediction model
EDAT- 2017/10/31 06:00
MHDA- 2019/06/04 06:00
CRDT- 2017/10/31 06:00
PHST- 2017/10/31 06:00 [pubmed]
PHST- 2019/06/04 06:00 [medline]
PHST- 2017/10/31 06:00 [entrez]
AID - 10.1253/circj.CJ-17-0549 [doi]
PST - ppublish
SO  - Circ J. 2018 Feb 23;82(3):699-707. doi: 10.1253/circj.CJ-17-0549. Epub 2017 Oct 
      27.