PMID- 29081891
OWN - NLM
STAT- MEDLINE
DCOM- 20180702
LR  - 20240327
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2017
DP  - 2017
TI  - NRF2 Is a Potential Modulator of Hyperresistance to Arsenic Toxicity in Stem-Like 
      Keratinocytes.
PG  - 7417694
LID - 10.1155/2017/7417694 [doi]
LID - 7417694
AB  - Arsenic is a well-known human carcinogen. Stem cells are indicated to be involved 
      in arsenic carcinogenesis and have a survival selection advantage during arsenic 
      exposure with underlying mechanisms undefined. In the present study, we 
      demonstrated that CD34(high)-enriched cells derived from HaCaT human 
      keratinocytes showed stem-like phenotypes. These cells were more resistant to 
      arsenic toxicity and had higher arsenic efflux ability than their mature 
      compartments. The master transcription factor in antioxidant defense, nuclear 
      factor erythroid 2-related factor 2 (NRF2) with its downstream genes, was highly 
      expressed in CD34(high)-enriched cells. Stable knockdown of NRF2 abolished the 
      hyperresistance to arsenic toxicity and holoclone-forming ability of 
      CD34(high)-enriched cells. Our results suggest that skin epithelial 
      stem/progenitor cells are more resistant to arsenic toxicity than mature cells, 
      which is associated with the high innate expression of NRF2 in skin epithelial 
      stem/progenitor cells.
FAU - Wu, Xiafang
AU  - Wu X
AD  - Program of Environmental Toxicology, School of Public Health, China Medical 
      University, Shenyang, Liaoning, China.
FAU - Yang, Bei
AU  - Yang B
AUID- ORCID: 0000-0003-3925-6399
AD  - Department of Histology and Embryology, College of Basic Medical Sciences, China 
      Medical University, Shenyang, Liaoning, China.
FAU - Hu, Yuxin
AU  - Hu Y
AD  - Experimental Teaching Center, School of Public Health, China Medical University, 
      Shenyang, Liaoning, China.
FAU - Sun, Ru
AU  - Sun R
AD  - Program of Environmental Toxicology, School of Public Health, China Medical 
      University, Shenyang, Liaoning, China.
FAU - Wang, Huihui
AU  - Wang H
AD  - Program of Environmental Toxicology, School of Public Health, China Medical 
      University, Shenyang, Liaoning, China.
FAU - Fu, Jingqi
AU  - Fu J
AD  - Program of Environmental Toxicology, School of Public Health, China Medical 
      University, Shenyang, Liaoning, China.
FAU - Hou, Yongyong
AU  - Hou Y
AD  - Program of Environmental Toxicology, School of Public Health, China Medical 
      University, Shenyang, Liaoning, China.
FAU - Pi, Jingbo
AU  - Pi J
AUID- ORCID: 0000-0003-0227-8041
AD  - Program of Environmental Toxicology, School of Public Health, China Medical 
      University, Shenyang, Liaoning, China.
AD  - Experimental Teaching Center, School of Public Health, China Medical University, 
      Shenyang, Liaoning, China.
FAU - Xu, Yuanyuan
AU  - Xu Y
AUID- ORCID: 0000-0003-2354-9453
AD  - Program of Environmental Toxicology, School of Public Health, China Medical 
      University, Shenyang, Liaoning, China.
AD  - Experimental Teaching Center, School of Public Health, China Medical University, 
      Shenyang, Liaoning, China.
LA  - eng
PT  - Journal Article
DEP - 20170910
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (NF-E2-Related Factor 2)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Arsenic/*toxicity
MH  - Humans
MH  - Keratinocytes/*drug effects
MH  - NF-E2-Related Factor 2/*metabolism
PMC - PMC5610874
EDAT- 2017/10/31 06:00
MHDA- 2018/07/03 06:00
PMCR- 2017/09/10
CRDT- 2017/10/31 06:00
PHST- 2017/01/20 00:00 [received]
PHST- 2017/07/07 00:00 [revised]
PHST- 2017/08/01 00:00 [accepted]
PHST- 2017/10/31 06:00 [entrez]
PHST- 2017/10/31 06:00 [pubmed]
PHST- 2018/07/03 06:00 [medline]
PHST- 2017/09/10 00:00 [pmc-release]
AID - 10.1155/2017/7417694 [doi]
PST - ppublish
SO  - Oxid Med Cell Longev. 2017;2017:7417694. doi: 10.1155/2017/7417694. Epub 2017 Sep 
      10.