PMID- 29082244
OWN - NLM
STAT- MEDLINE
DCOM- 20180612
LR  - 20181113
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2017
DP  - 2017
TI  - Expression Levels and Clinical Significance of miR-21-5p, miR-let-7a, and 
      miR-34c-5p in Laryngeal Squamous Cell Carcinoma.
PG  - 3921258
LID - 10.1155/2017/3921258 [doi]
LID - 3921258
AB  - OBJECTIVE: Altered microRNAs (miRNAs) expression has been found in many cancer 
      types, including laryngeal squamous cell carcinoma (LSCC). The aim of this study 
      was to determine the role and clinical value of three LSCC-related miRs, such as 
      miR-21-5p, miR-let-7a, and miR-34c-5p in a homogeneous cohort of patients with 
      primary LSCC treated by primary surgery. METHODS: Expression levels of miR-21-5p, 
      miR-let-7a, and miR-34c-5p were detected in 43 pairs of LSCC and adjacent normal 
      tissues by reverse-transcription quantitative PCR. Overall survival and 
      disease-free survival were evaluated using the Kaplan-Meier method, and 
      multivariate analysis was performed using the Cox proportional hazard analysis. 
      RESULTS: miR-21-5p is significantly upregulated, while miR-let-7a is 
      significantly downregulated in LSCC tumor tissues compared with the corresponding 
      adjacent normal tissues. The downregulation of miR-34c-5p expression 
      significantly correlated with a shorter disease-free survival and, in the 
      multivariate analysis, low miR-34c-5p expression was associated with an increased 
      risk of recurrence. CONCLUSIONS: miR-21-5p, miR-let-7a, and miR-34c-5p seem to 
      play a critical role in LSCC carcinogenesis and might have a diagnostic and 
      prognostic clinical value. The miR-let-7a levels could have a predictive role for 
      lymph node metastases and miR-34c-5p might be a promising biomarker of patient 
      outcome.
FAU - Re, Massimo
AU  - Re M
AUID- ORCID: 0000-0002-0919-2155
AD  - Department of Otorhinolaryngology, Umberto I University General Hospital, 
      Universita Politecnica delle Marche, Via Conca 71, 60126 Ancona, Italy.
FAU - Magliulo, Giuseppe
AU  - Magliulo G
AUID- ORCID: 0000-0003-3052-1969
AD  - Department of Otorhinolaryngology, Audiology and Phoniatrics "G. Ferreri", 
      University La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy.
FAU - Gioacchini, Federico M
AU  - Gioacchini FM
AD  - Department of Otorhinolaryngology, Umberto I University General Hospital, 
      Universita Politecnica delle Marche, Via Conca 71, 60126 Ancona, Italy.
FAU - Bajraktari, Arisa
AU  - Bajraktari A
AUID- ORCID: 0000-0003-3924-4953
AD  - Department of Otorhinolaryngology, Umberto I University General Hospital, 
      Universita Politecnica delle Marche, Via Conca 71, 60126 Ancona, Italy.
FAU - Bertini, Andrea
AU  - Bertini A
AUID- ORCID: 0000-0003-4548-6967
AD  - Department of Otorhinolaryngology, Umberto I University General Hospital, 
      Universita Politecnica delle Marche, Via Conca 71, 60126 Ancona, Italy.
FAU - Ceka, Artan
AU  - Ceka A
AD  - Department of Molecular and Clinical Sciences, Universita Politecnica delle 
      Marche, Via Tronto 10/a, 60126 Ancona, Italy.
FAU - Rubini, Corrado
AU  - Rubini C
AD  - Pathologic Anatomy and Histopathology Division, Department of Biomedical Sciences 
      and Public Health, Universita Politecnica delle Marche, Via Conca 71, 60126 
      Ancona, Italy.
FAU - Ferrante, Luigi
AU  - Ferrante L
AD  - Department of Biomedical Sciences and Public Health, Section of Medical 
      Statistics, Faculty of Medicine, Universita Politecnica delle Marche, Via Tronto 
      10/a, 60126 Ancona, Italy.
FAU - Procopio, Antonio D
AU  - Procopio AD
AD  - Department of Molecular and Clinical Sciences, Universita Politecnica delle 
      Marche, Via Tronto 10/a, 60126 Ancona, Italy.
AD  - Center of Clinical Pathology and Innovative Therapy, INRCA-IRCCS Italian National 
      Institute, Via della Montagnola 81, 60127 Ancona, Italy.
FAU - Olivieri, Fabiola
AU  - Olivieri F
AD  - Department of Molecular and Clinical Sciences, Universita Politecnica delle 
      Marche, Via Tronto 10/a, 60126 Ancona, Italy.
AD  - Center of Clinical Pathology and Innovative Therapy, INRCA-IRCCS Italian National 
      Institute, Via della Montagnola 81, 60127 Ancona, Italy.
LA  - eng
PT  - Journal Article
DEP - 20170831
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MIRN21 microRNA, human)
RN  - 0 (MIRN34 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (mirnlet7 microRNA, human)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/genetics
MH  - Carcinogenesis/genetics
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Disease-Free Survival
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - MicroRNAs/*genetics
MH  - Middle Aged
MH  - Prognosis
PMC - PMC5610801
EDAT- 2017/10/31 06:00
MHDA- 2018/06/13 06:00
PMCR- 2017/08/31
CRDT- 2017/10/31 06:00
PHST- 2017/02/26 00:00 [received]
PHST- 2017/08/01 00:00 [accepted]
PHST- 2017/10/31 06:00 [entrez]
PHST- 2017/10/31 06:00 [pubmed]
PHST- 2018/06/13 06:00 [medline]
PHST- 2017/08/31 00:00 [pmc-release]
AID - 10.1155/2017/3921258 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:3921258. doi: 10.1155/2017/3921258. Epub 2017 Aug 31.