PMID- 29082262
OWN - NLM
STAT- MEDLINE
DCOM- 20180618
LR  - 20221207
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2017
DP  - 2017
TI  - Vitamin D Supplementation Improves Mood in Women with Type 2 Diabetes.
PG  - 8232863
LID - 10.1155/2017/8232863 [doi]
LID - 8232863
AB  - OBJECTIVE: The aim of this study was to determine the effect of vitamin D 
      supplementation on improving mood (depression and anxiety) and health status 
      (mental and physical) in women with type 2 diabetes mellitus (T2DM). METHODS: 
      Fifty women with T2DM and significant depressive symptomology were enrolled into 
      the "Sunshine Study," where weekly vitamin D supplementation (ergocalciferol, 
      50,000 IU) was given to all participants for six months. The main outcomes 
      included (1) depression (Center for Epidemiologic Studies Depression, CES-D, and 
      Patient Health Questionnaire, PHQ-9), (2) anxiety (State-Trait Anxiety), and (3) 
      health status (Short Form, SF-12). RESULTS: Forty-six women (92%) completed all 
      visits. There was a significant decrease in depression (CES-D and PHQ-9, p < 
      0.001) and anxiety (state and trait, p < 0.001). An improvement in mental health 
      status (SF-12, p < 0.001) was also found. After controlling for covariates (race, 
      season of enrollment, baseline vitamin D, baseline depression (PHQ-9), and body 
      mass index), the decline in depression remained significant (CES-D, p < 0.001). 
      There was a trend for a better response to supplementation for women who were not 
      taking medications for mood (antidepressants or anxiolytics) (p = 0.07). 
      CONCLUSIONS: Randomized trials to confirm that vitamin D supplementation can 
      improve mood and health status in T2DM women are needed.
FAU - Penckofer, Sue
AU  - Penckofer S
AUID- ORCID: 0000-0003-3497-9280
AD  - Loyola University Chicago, Health Sciences Campus, 2160 S. First Avenue, Maywood, 
      IL 60153, USA.
FAU - Byrn, Mary
AU  - Byrn M
AD  - Loyola University Chicago, Health Sciences Campus, 2160 S. First Avenue, Maywood, 
      IL 60153, USA.
FAU - Adams, William
AU  - Adams W
AD  - Loyola University Chicago, Health Sciences Campus, 2160 S. First Avenue, Maywood, 
      IL 60153, USA.
FAU - Emanuele, Mary Ann
AU  - Emanuele MA
AD  - Loyola University Chicago, Health Sciences Campus, 2160 S. First Avenue, Maywood, 
      IL 60153, USA.
FAU - Mumby, Patricia
AU  - Mumby P
AD  - Loyola University Chicago, Health Sciences Campus, 2160 S. First Avenue, Maywood, 
      IL 60153, USA.
FAU - Kouba, Joanne
AU  - Kouba J
AD  - Loyola University Chicago, Health Sciences Campus, 2160 S. First Avenue, Maywood, 
      IL 60153, USA.
FAU - Wallis, Diane E
AU  - Wallis DE
AD  - Advocate Medical Group, 3825 Highland Avenue, Suite 400, Downers Grove, IL 60515, 
      USA.
LA  - eng
GR  - P30 DK020595/DK/NIDDK NIH HHS/United States
GR  - P30 DK092949/DK/NIDDK NIH HHS/United States
GR  - P60 DK020595/DK/NIDDK NIH HHS/United States
GR  - R01 NR013906/NR/NINR NIH HHS/United States
PT  - Journal Article
DEP - 20170907
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Biomarkers)
RN  - 0 (Ergocalciferols)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Adult
MH  - Affect/*drug effects
MH  - Anxiety/blood/diagnosis/*drug therapy/psychology
MH  - Biomarkers/blood
MH  - Depression/blood/diagnosis/*drug therapy/psychology
MH  - Diabetes Mellitus, Type 2/blood/diagnosis/*drug therapy/psychology
MH  - *Dietary Supplements
MH  - Ergocalciferols/*administration & dosage
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - *Mental Health
MH  - Middle Aged
MH  - Proof of Concept Study
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Treatment Outcome
MH  - Vitamin D/blood
MH  - Vitamin D Deficiency/blood/diagnosis/*drug therapy/psychology
PMC - PMC5610883
EDAT- 2017/10/31 06:00
MHDA- 2018/06/19 06:00
PMCR- 2017/09/07
CRDT- 2017/10/31 06:00
PHST- 2017/04/28 00:00 [received]
PHST- 2017/07/27 00:00 [accepted]
PHST- 2017/10/31 06:00 [entrez]
PHST- 2017/10/31 06:00 [pubmed]
PHST- 2018/06/19 06:00 [medline]
PHST- 2017/09/07 00:00 [pmc-release]
AID - 10.1155/2017/8232863 [doi]
PST - ppublish
SO  - J Diabetes Res. 2017;2017:8232863. doi: 10.1155/2017/8232863. Epub 2017 Sep 7.