PMID- 29082263
OWN - NLM
STAT- MEDLINE
DCOM- 20180618
LR  - 20211204
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2017
DP  - 2017
TI  - Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 
      Diabetes.
PG  - 8293207
LID - 10.1155/2017/8293207 [doi]
LID - 8293207
AB  - The objectives of the study were to investigate serum ANGPTL8 concentrations in 
      different glucose metabolic statuses and to explore the correlations between 
      serum ANGPTL8 levels and various metabolic parameters. Serum ANGPTL8 levels were 
      determined using ELISA in 22 subjects with NGT (normal glucose tolerance), 74 
      subjects with IGR (impaired glucose regulation), and 33 subjects with T2DM (type 
      2 diabetes mellitus). Subjects with IFG, IGT, CGI, and T2DM had higher levels of 
      serum ANGPTL8 than subjects with NGT. Serum ANGPTL8 was positively correlated 
      with FPG, fasting C-peptide, and postprandial C-peptide and negatively correlated 
      with BETA/IR when adjusted for age and BMI. Multivariate analysis suggested FPG 
      and fasting C-peptide as independent factors associated with serum ANGPTL8 
      levels. Serum ANGPTL8 concentrations were significantly increased in IGR and 
      T2DM. Serum ANGPTL8 might play a role in the pathological mechanism of glucose 
      intolerance.
FAU - Yin, Yanhua
AU  - Yin Y
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, China.
FAU - Ding, Xiaoying
AU  - Ding X
AUID- ORCID: 0000-0001-6290-8485
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, China.
FAU - Peng, Liang
AU  - Peng L
AD  - Department of Clinical Laboratory Center, Shanghai Songjiang District Central 
      Hospital, Shanghai 200080, China.
FAU - Hou, Yanqiang
AU  - Hou Y
AUID- ORCID: 0000-0002-5677-9821
AD  - Department of Clinical Laboratory Center, Shanghai Songjiang District Central 
      Hospital, Shanghai 200080, China.
FAU - Ling, Yunxia
AU  - Ling Y
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, China.
FAU - Gu, Mingyu
AU  - Gu M
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, China.
FAU - Wang, Yufan
AU  - Wang Y
AUID- ORCID: 0000-0001-9614-3986
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, China.
FAU - Peng, Yongde
AU  - Peng Y
AUID- ORCID: 0000-0001-9388-4922
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, China.
FAU - Sun, Haiyan
AU  - Sun H
AUID- ORCID: 0000-0002-8817-1570
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, China.
LA  - eng
PT  - Journal Article
DEP - 20170907
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (ANGPTL8 protein, human)
RN  - 0 (Angiopoietin-Like Protein 8)
RN  - 0 (Angiopoietin-like Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Peptide Hormones)
SB  - IM
MH  - Angiopoietin-Like Protein 8
MH  - Angiopoietin-like Proteins/*blood
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - C-Peptide/blood
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/diagnosis
MH  - Female
MH  - Glucose Intolerance/*blood/diagnosis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Peptide Hormones/*blood
MH  - Prediabetic State/*blood/diagnosis
MH  - Up-Regulation
PMC - PMC5610791
EDAT- 2017/10/31 06:00
MHDA- 2018/06/19 06:00
PMCR- 2017/09/07
CRDT- 2017/10/31 06:00
PHST- 2016/12/31 00:00 [received]
PHST- 2017/05/16 00:00 [accepted]
PHST- 2017/10/31 06:00 [entrez]
PHST- 2017/10/31 06:00 [pubmed]
PHST- 2018/06/19 06:00 [medline]
PHST- 2017/09/07 00:00 [pmc-release]
AID - 10.1155/2017/8293207 [doi]
PST - ppublish
SO  - J Diabetes Res. 2017;2017:8293207. doi: 10.1155/2017/8293207. Epub 2017 Sep 7.