PMID- 29082469
OWN - NLM
STAT- MEDLINE
DCOM- 20180720
LR  - 20191210
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 63
IP  - 3-4
DP  - 2017 Dec
TI  - Evaluation of the Effect of Moringa peregrina Extract on Learning and Memory: 
      Role of Oxidative Stress.
PG  - 355-363
LID - 10.1007/s12031-017-0986-x [doi]
AB  - Oxidative stress interferes with the functional roles of the hippocampus and 
      results in cognitive decline. Antioxidant supplementation has a cognitive 
      enhancing activity through protecting hippocampus brain cells from the damaging 
      effects of the reactive oxygen species. The dried methanolic extract of the 
      aboveground parts of Moringa peregrina (Forssk.) Fiori (Moringaceae) was 
      hypothesized to have memory-enhancing activity via its antioxidative properties. 
      HPLC and LC-MS methods were used for qualitative analysis of the marker 
      compounds. Six major compounds of the methanolic extract of M. peregrina were 
      identified, namely, rutin, myricetin, alpha-amyrin, beta-amyrin, lupeol acetate, and 
      beta-sitosterol. Male Wistar rats were administered via oral gavage three dose 
      levels (50, 100, and 500 mg/kg) of M. peregrina methanolic extract for 2 months. 
      The radial arm water maze (RAWM) was used to test spatial learning and memory. In 
      addition, ELISA was used to analyze the levels of brain-derived neurotrophic 
      factor (BDNF) and to assess the level of some oxidative stress markers. M. 
      peregrina (150 mg/kg) resulted in short- and long-term memory enhancement 
      (P < 0.05). Moreover, M. peregrina administration elevated BDNF levels in the 
      hippocampus (P < 0.05) and caused favorable changes in oxidative stress 
      biomarkers. In particular, an increase in glutathione (GSH), a decrease in 
      oxidized glutathione (GSSG), and an increase in the antioxidant enzyme 
      glutathione peroxidase (GPx) levels in the hippocampus were elicited after 
      treatment with M. peregrina. Taken together, our data show that oral 
      administration of M. peregrina enhances both short- and long-term memory 
      functions via combating oxidative stress and increasing BDNF levels in the 
      hippocampus. Consuming this safe plant may thus help promote spatial learning and 
      improve memory.
FAU - Alzoubi, Karem H
AU  - Alzoubi KH
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of 
      Science and Technology, Irbid, 22110, Jordan.
FAU - Rawashdeh, Nasab Q
AU  - Rawashdeh NQ
AD  - National Center for Agricultural Research and Extension, Baq'a, Amman, Jordan.
FAU - Khabour, Omar F
AU  - Khabour OF
AD  - Department of Medical Laboratory Sciences, Jordan University of Science and 
      Technology, Irbid, 22110, Jordan.
AD  - Faculty of Applied Medical Sciences, Taibah University, Medina, Saudi Arabia.
FAU - El-Elimat, Tamam
AU  - El-Elimat T
AD  - Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan 
      University of Science and Technology, Irbid, 22110, Jordan.
FAU - Albataineh, Hanan
AU  - Albataineh H
AD  - Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan 
      University of Science and Technology, Irbid, 22110, Jordan.
FAU - Al-Zghool, Hamzeh M
AU  - Al-Zghool HM
AD  - Faculty of Medicine, Hashemite University, Zarqa, Jordan.
FAU - Alali, Feras Q
AU  - Alali FQ
AD  - College of Pharmacy, Qatar University, Doha, 2713, Qatar. Feras.alali@qu.edu.qa.
LA  - eng
GR  - Agr/2/02/2010/Scientific Research Support Fund, Ministry of Higher Education and 
      Scientific Research/
PT  - Journal Article
DEP - 20171030
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Flavonoids)
RN  - 0 (Pentacyclic Triterpenes)
RN  - 0 (Plant Extracts)
RN  - 0 (Sitosterols)
RN  - 5G06TVY3R7 (Rutin)
RN  - 5LI01C78DD (gamma-sitosterol)
RN  - 6SMK8R7TGJ (Oleanolic Acid)
RN  - 76XC01FTOJ (myricetin)
RN  - KM8353IPSO (beta-amyrin)
RN  - O268W13H3O (lupeol)
SB  - IM
MH  - Animals
MH  - Antioxidants/chemistry/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Flavonoids/analysis
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - Maze Learning/*drug effects
MH  - Memory/*drug effects
MH  - Moringa/*chemistry
MH  - Oleanolic Acid/analogs & derivatives/analysis
MH  - *Oxidative Stress
MH  - Pentacyclic Triterpenes/analysis
MH  - Plant Extracts/chemistry/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Rutin/analysis
MH  - Sitosterols/analysis
OTO - NOTNLM
OT  - Antioxidant
OT  - Cognition
OT  - Hippocampus
OT  - Learning
OT  - Memory
OT  - Moringa peregrina
EDAT- 2017/10/31 06:00
MHDA- 2018/07/22 06:00
CRDT- 2017/10/31 06:00
PHST- 2017/08/06 00:00 [received]
PHST- 2017/10/05 00:00 [accepted]
PHST- 2017/10/31 06:00 [pubmed]
PHST- 2018/07/22 06:00 [medline]
PHST- 2017/10/31 06:00 [entrez]
AID - 10.1007/s12031-017-0986-x [pii]
AID - 10.1007/s12031-017-0986-x [doi]
PST - ppublish
SO  - J Mol Neurosci. 2017 Dec;63(3-4):355-363. doi: 10.1007/s12031-017-0986-x. Epub 
      2017 Oct 30.