PMID- 29085093 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220408 IS - 0019-5545 (Print) IS - 1998-3794 (Electronic) IS - 0019-5545 (Linking) VI - 59 IP - 3 DP - 2017 Jul-Sep TI - A cross-sectional comparative study on the assessment of quality of life in psychiatric patients under remission treated with monotherapy and polypharmacy. PG - 333-340 LID - 10.4103/psychiatry.IndianJPsychiatry_126_16 [doi] AB - CONTEXT: The concept of quality of life (QoL) is becoming an important measure of the impact of psychiatric disorders. It is natural that once patient achieves remission, QoL would improve, but very few studies are conducted under this phase. This study compares the differences in QoL in remitted patients with monotherapy and polypharmacy. AIMS: The aim of this study is to compare the QoL between psychiatric patients in remission treated with monotherapy and polypharmacy. SETTINGS AND DESIGN: It is a questionnaire based cross-sectional comparative study. MATERIALS AND METHODS: This study included outpatients under remission who come for follow-up in psychiatric department. Semi-structured data collection form was used. Remission was confirmed using suitable scales, and QoL was assessed using the World Health Organization quality of life-Brief (WHOQOL-BREF) scale. Clinical Global Impression (CGI) and Global Assessment of Functioning (GAF) were applied to understand the overall improvement and functioning levels. RESULTS: Out of the total 100 patients enrolled in the study, fifty patients were on monotherapy and fifty patients on polypharmacy. The cost of medication was comparatively high for polypharmacy (Rs. 3568.92 [+/-348.54]) than monotherapy (Rs. 1936.56 [+/-252.07]). The QoL in physical, psychological, and social domains was significantly high in patients on polypharmacy rather than monotherapy when assessed using the WHOQOL-BREF scale. Ninety-six percent of monotherapy patients had CGI scores between 1.5 and 2.4 while 74% of polypharmacy patients had scores between 1.0 and 1.5. Ninety-six percent of monotherapy patients had <80 GAF scores while 92% of polypharmacy patients had >80. CONCLUSIONS: Patients treated with polypharmacy had better QoL and also clinical improvement and functioning levels were superior. FAU - Koshy, Benson AU - Koshy B AD - Departments of Pharmacy Practice, SJMCP, Chitradurga, Karnataka, India. FAU - Gopal Das, C M AU - Gopal Das CM AD - Department of Psychiatry, BMCH and RC, Chitradurga, Karnataka, India. FAU - Rajashekarachar, Yogananda AU - Rajashekarachar Y AD - Department of Psychiatry, BMCH and RC, Chitradurga, Karnataka, India. FAU - Bharathi, D R AU - Bharathi DR AD - Department of Psychiatry, BMCH and RC, Chitradurga, Karnataka, India. FAU - Hosur, Shashank S AU - Hosur SS AD - Department of Psychiatry, BMCH and RC, Chitradurga, Karnataka, India. LA - eng PT - Journal Article PL - India TA - Indian J Psychiatry JT - Indian journal of psychiatry JID - 0013255 PMC - PMC5659084 OTO - NOTNLM OT - Monotherapy OT - polypharmacy OT - psychiatry OT - quality of life OT - remission COIS- There are no conflicts of interest. EDAT- 2017/11/01 06:00 MHDA- 2017/11/01 06:01 PMCR- 2017/07/01 CRDT- 2017/11/01 06:00 PHST- 2017/11/01 06:00 [entrez] PHST- 2017/11/01 06:00 [pubmed] PHST- 2017/11/01 06:01 [medline] PHST- 2017/07/01 00:00 [pmc-release] AID - IJPsy-59-333 [pii] AID - 10.4103/psychiatry.IndianJPsychiatry_126_16 [doi] PST - ppublish SO - Indian J Psychiatry. 2017 Jul-Sep;59(3):333-340. doi: 10.4103/psychiatry.IndianJPsychiatry_126_16.