PMID- 29085260
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1658-3639 (Print)
IS  - 1658-3639 (Linking)
VI  - 11
IP  - 4
DP  - 2017 Sep-Oct
TI  - Clinical study and assessment of leukocyte phagocytic function in children with 
      atopic dermatitis in Qassim region of Saudi Arabia.
PG  - 3-7
AB  - OBJECTIVE: Atopic dermatitis (AD) is a skin disorder clinically seen in the 
      pediatric population. It is well recognized that patients with AD have an 
      increased susceptibility to cutaneous colonization and infection with bacteria, 
      fungi, and viruses. This study was undertaken to investigate the phagocytic 
      activity and chemotactic response of mononuclear and polymorphonuclear leukocytes 
      in severe AD patients. METHODS: A total of 50 children with severe AD were 
      selected according to severity scoring of AD (the SCORAD index) and 30 healthy 
      children of same age and sex were also selected as controls. The mononuclear and 
      neutrophilic leukocytes were separated and the phagocytic ingestion of zymosan 
      particles was determined. Migration distance in response tobacterial 
      lipopolysaccharide chemotactic factor was also determined. Immunological 
      disturbance in AD patients was determined by sandwich enzyme-liked immunosorbent 
      assays for total serum immunoglobulin E (IgE), complement 3 (C3) C4. RESULTS: Of 
      50 AD patients with severe disease activity, 36 patients (72%) showed reduction 
      in mononuclear and neutrophilic phagocytic activity. Children with AD had higher 
      levels of total serum IgE, C3, and C4 compared to healthy children (P < 0.01). 
      CONCLUSIONS: The study results demonstrated an inhibition in the chemotactic 
      response and phagocytic activity by mononuclear and/or neutrophilic leukocytes in 
      severe AD patients. We further observed an involvement of perturb complement 
      system in patients with AD. Hence, we clearly showed that AD is exacerbated with 
      compromised immunological response, especially the innate immune response.
FAU - Abdullraheem, Yasser F
AU  - Abdullraheem YF
AD  - Department of Pediatric, College of Medicine, Qassim University, Saudi Arabia.
FAU - Alzolibani, Abullateef A
AU  - Alzolibani AA
AD  - Department of Dermatology, College of Medicine, Qassim University, Saudi Arabia.
FAU - Mahmoud, Khaleed H
AU  - Mahmoud KH
AD  - Department of Pediatric, College of Medicine, Qassim University, Saudi Arabia.
FAU - Korsni, Amani H
AU  - Korsni AH
AD  - Department of Pediatric, College of Medicine, Qassim University, Saudi Arabia.
FAU - Al-Harbi, Muhmmad Helyel
AU  - Al-Harbi MH
AD  - Intern, College of Medicine, Qassim University, Saudi Arabia.
FAU - Hassanin, Kaleed M
AU  - Hassanin KM
AD  - Department of Microbiology, College of Medicine, Assiut University, Egypt.
FAU - Al-Dhubaibi, Mohammed S
AU  - Al-Dhubaibi MS
AD  - Department of Dermatology, College of Medicine, Qassim University, Saudi Arabia.
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Int J Health Sci (Qassim)
JT  - International journal of health sciences
JID - 101528042
PMC - PMC5654183
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - chemotaxis
OT  - mononuclear leukocytes
OT  - neutrophils
OT  - phagocytic function
EDAT- 2017/11/01 06:00
MHDA- 2017/11/01 06:01
PMCR- 2017/09/01
CRDT- 2017/11/01 06:00
PHST- 2017/11/01 06:00 [entrez]
PHST- 2017/11/01 06:00 [pubmed]
PHST- 2017/11/01 06:01 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - IJHS-11-3 [pii]
PST - ppublish
SO  - Int J Health Sci (Qassim). 2017 Sep-Oct;11(4):3-7.