PMID- 29085373
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 8
DP  - 2017
TI  - Conventional CD11c(high) Dendritic Cells Are Important for T Cell Priming during 
      the Initial Phase of Plasmodium yoelii Infection, but Are Dispensable at Later 
      Time Points.
PG  - 1333
LID - 10.3389/fimmu.2017.01333 [doi]
LID - 1333
AB  - Dendritic cells (DCs) are highly specialized antigen-presenting cells that 
      orchestrate adaptive immune responses to pathogens. During malaria infection pro- 
      and anti-inflammatory T cell responses have to be tightly balanced to ensure 
      parasite clearance without induction of severe immune pathologies. However, the 
      precise role of CD11c(high) DCs in this process is still discussed 
      controversially. Here, we demonstrate that long-term depletion of conventional 
      CD11c(high) DCs in Plasmodium yoelii (P. yoelii)-infected diphtheria toxin 
      (DT)-treated RosaiDTR/CD11c-cre mice interferes with the activation of CD8(+) and 
      CD4(+) T cells as well as CD4(+)Foxp3(+) regulatory T cells at early time points 
      during infection. Moreover, systemic levels of the pro-inflammatory cytokines 
      IFN-gamma and TNF-alpha were decreased in P. yoelii-infected mice deficient for 
      CD11c(high) DCs compared to infected RosaiDTR controls. To further elucidate the 
      importance of CD11c(high) DCs during the later phase of infection, we treated 
      RosaiDTR/CD11c-cre and control mice with DT only from day 4 of P. yoelii 
      infection onward. Strikingly, this approach had no impact on the activation and 
      IFN-gamma production of CD4(+) and CD8(+) effector T cells. These results indicate 
      that CD11c(high) DCs play a crucial role in eliciting effector T cell responses 
      during the initial phase, but are dispensable during ongoing infection with P. 
      yoelii.
FAU - Ueffing, Kristina
AU  - Ueffing K
AD  - Institute of Medical Microbiology, University Hospital Essen, University 
      Duisburg-Essen, Essen, Germany.
FAU - Abberger, Hanna
AU  - Abberger H
AD  - Institute of Medical Microbiology, University Hospital Essen, University 
      Duisburg-Essen, Essen, Germany.
FAU - Westendorf, Astrid M
AU  - Westendorf AM
AD  - Institute of Medical Microbiology, University Hospital Essen, University 
      Duisburg-Essen, Essen, Germany.
FAU - Matuschewski, Kai
AU  - Matuschewski K
AD  - Molecular Parasitology, Institute of Biology, Humboldt University of Berlin, 
      Berlin, Germany.
FAU - Buer, Jan
AU  - Buer J
AD  - Institute of Medical Microbiology, University Hospital Essen, University 
      Duisburg-Essen, Essen, Germany.
FAU - Hansen, Wiebke
AU  - Hansen W
AD  - Institute of Medical Microbiology, University Hospital Essen, University 
      Duisburg-Essen, Essen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20171016
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC5650681
OTO - NOTNLM
OT  - T cells
OT  - dendritic cells
OT  - malaria
OT  - parasitic protozoan
OT  - rodent
EDAT- 2017/11/01 06:00
MHDA- 2017/11/01 06:01
PMCR- 2017/01/01
CRDT- 2017/11/01 06:00
PHST- 2017/07/27 00:00 [received]
PHST- 2017/10/02 00:00 [accepted]
PHST- 2017/11/01 06:00 [entrez]
PHST- 2017/11/01 06:00 [pubmed]
PHST- 2017/11/01 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2017.01333 [doi]
PST - epublish
SO  - Front Immunol. 2017 Oct 16;8:1333. doi: 10.3389/fimmu.2017.01333. eCollection 
      2017.