PMID- 29085586
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 20
IP  - 8
DP  - 2017 Aug
TI  - Frequencies of HLA-A, B and DRB1 alleles in a large normal population living in 
      the city of Mashhad, Northeastern Iran.
PG  - 940-943
LID - 10.22038/IJBMS.2017.9117 [doi]
AB  - OBJECTIVES: The population in Iran is a genetic admixture of the ancestral Aryan 
      and other populations neighboring Iran. Different ethnic groups in Iran show wide 
      regional distributions for many human leukocyte antigen (HLA) alleles. Therefore, 
      it is necessary and sensible to study the differences in HLA allele distribution 
      in different area. We studied the HLA class I and II allele frequencies in a 
      large unrelated healthy Iranian population from Mashhad in the Northeast region. 
      MATERIALS AND METHODS: Five hundred unrelated healthy adult individuals borne and 
      living in Mashhad, Northeast of Iran, were genotyped for HLA-A, B and HLA-DRB1 
      alleles using PCR with low resolution sequence specific primers (SSP-PCR) 
      technique. RESULTS: A total of 14 HLA-A, 24 HLA-B and 10 HLA-DRB1 alleles were 
      spread throughout the studied population with distinct allele frequencies. At the 
      HLA-A locus, HLA-A*02 was found to be the most frequent allele, with a frequency 
      of 20.9%. The most common HLA-B alleles was B*35 (16.4%). The two most common 
      observed alleles in HLA class II alleles were DRB1*15 (20.0%) followed by DRB1*13 
      (16.2%). CONCLUSION: This study is the first on the HLA class I and II allele 
      frequencies in Northeastern Iranian population living in Mashhad. Distribution of 
      HLA-A and B loci showed some similarities with those of other Iranians. Some 
      difference in HLA-DRB1 polymorphisms however was observed. Considering the highly 
      mixed population of Mashhad, the finding was not unexpected.
FAU - Esmaeili, Alireza
AU  - Esmaeili A
AD  - Immunology Research Center, Bu Ali Research Institute, School of Medicine, 
      Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Rabe, Shahrzad Zamani Taghizadeh
AU  - Rabe SZT
AD  - Immunology Research Center, Bu Ali Research Institute, School of Medicine, 
      Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Mahmoudi, Mahmoud
AU  - Mahmoudi M
AD  - Immunology Research Center, Department of Immunology and Allergy, School of 
      Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Rastin, Maryam
AU  - Rastin M
AD  - Immunology Research Center, Bu Ali Research Institute, School of Medicine, 
      Mashhad University of Medical Sciences, Mashhad, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC5651480
OTO - NOTNLM
OT  - Allele frequency
OT  - Complex
OT  - HLA polymorphism
OT  - Human leukocyte antigen
OT  - Iranian population
OT  - Major histocompatibility -
OT  - Polymerase chain reaction
EDAT- 2017/11/01 06:00
MHDA- 2017/11/01 06:01
PMCR- 2017/08/01
CRDT- 2017/11/01 06:00
PHST- 2017/11/01 06:00 [entrez]
PHST- 2017/11/01 06:00 [pubmed]
PHST- 2017/11/01 06:01 [medline]
PHST- 2017/08/01 00:00 [pmc-release]
AID - IJBMS-20-940 [pii]
AID - 10.22038/IJBMS.2017.9117 [doi]
PST - ppublish
SO  - Iran J Basic Med Sci. 2017 Aug;20(8):940-943. doi: 10.22038/IJBMS.2017.9117.