PMID- 29086097
OWN - NLM
STAT- MEDLINE
DCOM- 20180625
LR  - 20190203
IS  - 1435-1463 (Electronic)
IS  - 0300-9564 (Linking)
VI  - 124
IP  - 12
DP  - 2017 Dec
TI  - An exploratory study of BDNF and oxidative stress marker alterations in subacute 
      and chronic stroke patients affected by neuropathic pain.
PG  - 1557-1566
LID - 10.1007/s00702-017-1805-9 [doi]
AB  - Patients affected by stroke, particularly subacute stroke patients, often 
      complain of neuropathic pain (NP), which may severely impair their quality of 
      life. The aim of this exploratory study was to characterize NP and to investigate 
      whether there is a correlation between NP and serum brain-derived neurotrophic 
      factor (BDNF) and serum markers of oxidative stress. We enrolled 50 patients 
      divided in subacute (< 90 days from stroke onset) and chronic (> 90 and 
      180 < days from stroke onset). The Barthel Index, Deambulation Index, and Short 
      Form 36 were used to assess the patients' degree of disability and quality of 
      life. Pain-specific tools, namely the Numeric Rating Scale (NRS), Neuropathic 
      Pain Diagnostic questionnaire (DN4), and Neuropathic Pain Symptom Inventory 
      (NPSI), were also used. Serum levels of BDNF and markers of oxidative stress and 
      of metal status were evaluated: copper, iron, transferrin, ferritin, 
      ceruloplasmin concentration (iCp) and activity (eCp), Total Antioxidant status 
      (TAS), Cp/Tf ratio, eCp/iCp ratio, and non-ceruloplasmin bound copper (Non-Cp 
      Cu). We found the highest value of BDNF in subacute with NP (DN4 score >/= 4). The 
      TAS, Cp/Tf ratio, and eCp/iCp not only fell outside the normal reference range in 
      a high percentage of subacute and chronic patients, but were also found to be 
      related to specific NP symptoms. These preliminary results reveal altered BDNF 
      and oxidative stress indices in subacute stroke patients who complain of NP. 
      These investigative findings may shed more light on the mechanisms underlying NP 
      and consequently lead to a more tailored therapeutic and/or rehabilitation 
      procedure of subacute stroke patients.
FAU - Siotto, Mariacristina
AU  - Siotto M
AUID- ORCID: 0000-0003-0837-0594
AD  - Don Carlo Gnocchi ONLUS Foundation, P.le Morandi 6, 20121, Milan, Italy. 
      mary.siotto@gmail.com.
FAU - Aprile, Irene
AU  - Aprile I
AD  - Don Carlo Gnocchi ONLUS Foundation, P.le Morandi 6, 20121, Milan, Italy.
FAU - Simonelli, Ilaria
AU  - Simonelli I
AD  - AFaR Division, Service of Medical Statistics and Information Technology, 
      Fatebenefratelli Foundation for Health Research and Education, Lungotevere de' 
      Cenci, 5, Rome, Italy.
FAU - Pazzaglia, Costanza
AU  - Pazzaglia C
AD  - Don Carlo Gnocchi ONLUS Foundation, P.le Morandi 6, 20121, Milan, Italy.
FAU - Ventriglia, Mariacarla
AU  - Ventriglia M
AD  - AFaR Division, Fatebenefratelli Foundation for Health Research and Education, 
      Isola Tiberina, Rome, Italy.
FAU - Santoro, Massimo
AU  - Santoro M
AD  - Don Carlo Gnocchi ONLUS Foundation, P.le Morandi 6, 20121, Milan, Italy.
FAU - Imbimbo, Isabella
AU  - Imbimbo I
AD  - Don Carlo Gnocchi ONLUS Foundation, P.le Morandi 6, 20121, Milan, Italy.
FAU - Squitti, Rosanna
AU  - Squitti R
AD  - Molecular Marker Laboratory, IRCCS Istituto Centro San Giovanni di 
      Dio-Fatebenefratelli, Brescia, Italy.
FAU - Padua, Luca
AU  - Padua L
AD  - Don Carlo Gnocchi ONLUS Foundation, P.le Morandi 6, 20121, Milan, Italy.
AD  - Department of Geriatrics, Neurosciences and Orthopaedics, Catholic University of 
      the Sacred Heart, Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20171030
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Metals)
RN  - 0 (Transferrin)
RN  - 9007-73-2 (Ferritins)
RN  - EC 1.16.3.1 (Ceruloplasmin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antioxidants/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Ceruloplasmin/metabolism
MH  - Disability Evaluation
MH  - Female
MH  - Ferritins/blood
MH  - Humans
MH  - Male
MH  - Metals/blood
MH  - Middle Aged
MH  - Neuralgia/*blood/*etiology
MH  - Oxidative Stress/physiology
MH  - Pain Measurement
MH  - Quality of Life
MH  - Statistics, Nonparametric
MH  - Stroke/*complications/psychology
MH  - Transferrin/metabolism
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - Ceruloplasmin-specific activity
OT  - Chronic stroke
OT  - Cp/Tf ratio
OT  - Neuropathic pain
OT  - Subacute stroke
OT  - Total antioxidant status
EDAT- 2017/11/01 06:00
MHDA- 2018/06/26 06:00
CRDT- 2017/11/01 06:00
PHST- 2017/07/06 00:00 [received]
PHST- 2017/10/17 00:00 [accepted]
PHST- 2017/11/01 06:00 [pubmed]
PHST- 2018/06/26 06:00 [medline]
PHST- 2017/11/01 06:00 [entrez]
AID - 10.1007/s00702-017-1805-9 [pii]
AID - 10.1007/s00702-017-1805-9 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2017 Dec;124(12):1557-1566. doi: 
      10.1007/s00702-017-1805-9. Epub 2017 Oct 30.