PMID- 29086908
OWN - NLM
STAT- MEDLINE
DCOM- 20180828
LR  - 20190401
IS  - 1995-8218 (Electronic)
IS  - 1673-7067 (Print)
IS  - 1995-8218 (Linking)
VI  - 34
IP  - 2
DP  - 2018 Apr
TI  - Melatonin Augments the Effects of Fluoxetine on Depression-Like Behavior and 
      Hippocampal BDNF-TrkB Signaling.
PG  - 303-311
LID - 10.1007/s12264-017-0189-z [doi]
AB  - Depression is a debilitating psychiatric disorder with a huge socioeconomic 
      burden, and its treatment relies on antidepressants including selective serotonin 
      reuptake inhibitors (SSRIs). Recently, the melatonergic system that is closely 
      associated with the serotonergic system has been implicated in the 
      pathophysiology and treatment of depression. However, it remains unknown whether 
      combined treatment with SSRI and melatonin has synergistic antidepressant 
      effects. In this study, we applied a sub-chronic restraint stress paradigm, and 
      evaluated the potential antidepressant effects of combined fluoxetine and 
      melatonin in adult male mice. Sub-chronic restraint stress (6 h/day for 10 days) 
      induced depression-like behavior as shown by deteriorated fur state, increased 
      latency to groom in the splash test, and increased immobility time in the 
      forced-swim test. Repeated administration of either fluoxetine or melatonin at 
      10 mg/kg during stress exposure failed to prevent depression-like phenotypes. 
      However, combined treatment with fluoxetine and melatonin at the selected dose 
      attenuated stress-induced behavioral abnormalities. Moreover, we found that the 
      antidepressant effects of combined treatment were associated with the 
      normalization of brain-derived neurotrophic factor (BDNF)-tropomyosin receptor 
      kinase B (TrkB) signaling in the hippocampus, but not in the prefrontal cortex. 
      Our findings suggest that combined fluoxetine and melatonin treatment exerts 
      synergistic antidepressant effects possibly by restoring hippocampal BDNF-TrkB 
      signaling.
FAU - Li, Kun
AU  - Li K
AD  - Department of Neurobiology, Key Laboratory of Medical Neurobiology of the 
      Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, 
      Zhejiang University School of Medicine, Hangzhou, 310058, China.
FAU - Shen, Si
AU  - Shen S
AD  - Zhejiang University School of Medicine, Hangzhou, 310058, China.
FAU - Ji, Yu-Tian
AU  - Ji YT
AD  - Zhejiang University School of Medicine, Hangzhou, 310058, China.
FAU - Li, Xu-Yun
AU  - Li XY
AD  - Experimental Teaching Center of Basic Medicine, Zhejiang University School of 
      Medicine, Hangzhou, 310058, China.
FAU - Zhang, Li-San
AU  - Zhang LS
AD  - Department of Neurology, Sir Run Run Shaw Hospital, Zhejiang University School of 
      Medicine, Hangzhou, 310016, China.
FAU - Wang, Xiao-Dong
AU  - Wang XD
AD  - Department of Neurobiology, Key Laboratory of Medical Neurobiology of the 
      Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, 
      Zhejiang University School of Medicine, Hangzhou, 310058, China. 
      xiaodongwang@zju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20171031
PL  - Singapore
TA  - Neurosci Bull
JT  - Neuroscience bulletin
JID - 101256850
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Glycoproteins)
RN  - 01K63SUP8D (Fluoxetine)
RN  - EC 2.7.10.1 (Ntrk2 protein, mouse)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Behavior, Animal/*drug effects
MH  - Brain-Derived Neurotrophic Factor/drug effects/metabolism
MH  - *Depression
MH  - Drug Synergism
MH  - Drug Therapy, Combination
MH  - Fluoxetine/*pharmacology
MH  - Hippocampus/*drug effects/metabolism
MH  - Male
MH  - Melatonin/*pharmacology
MH  - Membrane Glycoproteins/drug effects/metabolism
MH  - Mice, Inbred C57BL
MH  - Protein-Tyrosine Kinases/drug effects/metabolism
MH  - Restraint, Physical
MH  - Signal Transduction/drug effects
PMC - PMC5856716
OTO - NOTNLM
OT  - BDNF
OT  - Depression
OT  - Fluoxetine
OT  - Melatonin
OT  - TrkB
EDAT- 2017/11/01 06:00
MHDA- 2018/08/29 06:00
PMCR- 2019/04/01
CRDT- 2017/11/01 06:00
PHST- 2017/06/01 00:00 [received]
PHST- 2017/09/14 00:00 [accepted]
PHST- 2017/11/01 06:00 [pubmed]
PHST- 2018/08/29 06:00 [medline]
PHST- 2017/11/01 06:00 [entrez]
PHST- 2019/04/01 00:00 [pmc-release]
AID - 10.1007/s12264-017-0189-z [pii]
AID - 189 [pii]
AID - 10.1007/s12264-017-0189-z [doi]
PST - ppublish
SO  - Neurosci Bull. 2018 Apr;34(2):303-311. doi: 10.1007/s12264-017-0189-z. Epub 2017 
      Oct 31.