PMID- 29087612
OWN - NLM
STAT- MEDLINE
DCOM- 20191009
LR  - 20191010
IS  - 1523-4681 (Electronic)
IS  - 0884-0431 (Linking)
VI  - 33
IP  - 3
DP  - 2018 Mar
TI  - Bone Status Among Patients With Nonsurgical Hypoparathyroidism, Autosomal 
      Dominant Hypocalcaemia, and Pseudohypoparathyroidism: A Cohort Study.
PG  - 467-477
LID - 10.1002/jbmr.3328 [doi]
AB  - Nonsurgical hypoparathyroidism (Ns-HypoPT) and pseudohypoparathyroidism (PHP) are 
      both rare diseases, characterized by hypocalcemia. In Ns-HypoPT, PTH levels are 
      low, whereas patients with PHP often have very high levels due to 
      receptor-insensitivity to PTH (PTH-resistance). Accordingly, we hypothesized that 
      indices of bone turnover and bone mineralization/architecture are similar in 
      Ns-HypoPT and PHP despite marked differences in PTH levels. We studied 62 
      patients with Ns-HypoPT and 31 with PHP as well as a group of age- and 
      sex-matched healthy controls. We found a significantly higher areal BMD (aBMD) by 
      DXA among patients with Ns-HypoPT, both compared with PHP and the background 
      population. Compared with Ns-HypoPT, PHP patients had significantly lower total 
      and trabecular volumetric BMD (vBMD) assessed by quantitative computed tomography 
      (QCT) scans at the spine and hip. High-resolution peripheral quantitative 
      computed tomography (HRpQCT) scans showed a lower trabecular area and vBMD as 
      well as a lower trabecular number at the tibia in PHP compared to Ns-HypoPT and 
      matched controls. In PHP, PTH levels correlated with levels of markers of bone 
      formation (osteocalcin, bone-specific alkaline phosphatase, P1NP), and bone 
      resorption (CTx). In adult males, levels of bone markers were significantly 
      higher in PHP compared with Ns-HypoPT. Levels of procalcitonin and calcitonin 
      were significantly higher in PHP compared with Ns-HypoPT. In conclusion, indices 
      of bone turnover, density, and microarchitecture differ between patients with 
      Ns-HypoPT and PHP. Our data suggest that patients with PHP do not have a complete 
      skeletal resistance to PTH and that the effects of chronically high PTH levels in 
      PHP are mostly confined to the trabecular tissue. (c) 2017 American Society for 
      Bone and Mineral Research.
CI  - (c) 2017 American Society for Bone and Mineral Research.
FAU - Underbjerg, Line
AU  - Underbjerg L
AD  - Department of Endocrinology and Internal Medicine, Tage-Hansens Gade (THG), 
      Aarhus University Hospital, Aarhus, Denmark.
FAU - Malmstroem, Sofie
AU  - Malmstroem S
AD  - Department of Endocrinology and Internal Medicine, Tage-Hansens Gade (THG), 
      Aarhus University Hospital, Aarhus, Denmark.
FAU - Sikjaer, Tanja
AU  - Sikjaer T
AD  - Department of Endocrinology and Internal Medicine, Tage-Hansens Gade (THG), 
      Aarhus University Hospital, Aarhus, Denmark.
FAU - Rejnmark, Lars
AU  - Rejnmark L
AD  - Department of Endocrinology and Internal Medicine, Tage-Hansens Gade (THG), 
      Aarhus University Hospital, Aarhus, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171130
PL  - England
TA  - J Bone Miner Res
JT  - Journal of bone and mineral research : the official journal of the American 
      Society for Bone and Mineral Research
JID - 8610640
RN  - Hypercalciuric Hypocalcemia, Familial
SB  - IM
MH  - Adult
MH  - Bone Density
MH  - Bone and Bones/diagnostic imaging/*pathology
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Hypercalciuria/*complications/diagnostic imaging
MH  - Hypocalcemia/*complications/diagnostic imaging
MH  - Hypoparathyroidism/*complications/*congenital/diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Pseudohypoparathyroidism/*complications/diagnostic imaging
MH  - Radius/diagnostic imaging/pathology
MH  - Renal Insufficiency, Chronic/complications
MH  - Tibia/diagnostic imaging/pathology
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - DXA
OT  - HRPQCT
OT  - NONSURGICAL HYPOPARATHYROIDISM
OT  - PSEUDOHYPOPARATHYROIDISM
OT  - QCT
EDAT- 2017/11/01 06:00
MHDA- 2019/10/11 06:00
CRDT- 2017/11/01 06:00
PHST- 2017/08/02 00:00 [received]
PHST- 2017/10/27 00:00 [revised]
PHST- 2017/10/28 00:00 [accepted]
PHST- 2017/11/01 06:00 [pubmed]
PHST- 2019/10/11 06:00 [medline]
PHST- 2017/11/01 06:00 [entrez]
AID - 10.1002/jbmr.3328 [doi]
PST - ppublish
SO  - J Bone Miner Res. 2018 Mar;33(3):467-477. doi: 10.1002/jbmr.3328. Epub 2017 Nov 
      30.