PMID- 2908909
OWN - NLM
STAT- MEDLINE
DCOM- 19890126
LR  - 20071114
IS  - 0736-0266 (Print)
IS  - 0736-0266 (Linking)
VI  - 7
IP  - 1
DP  - 1989
TI  - The effects of demineralized bone matrix and direct current on an "in vivo" 
      culture of bone marrow cells.
PG  - 22-7
AB  - Bone marrow cells (BMCs) from rabbit femora and tibiae were grown in diffusion 
      chambers implanted in rabbit muscle. At 42 days 80% of the BMC chambers exhibited 
      cartilage formation within them. Demineralized bone matrix added to the marrow 
      cell suspension in the chamber accelerated the appearance and increased the 
      number of chambers with cartilage. Mineralization of the cartilage also occurred 
      earlier in the chambers with bone matrix. In a second experiment, a 5-microA 
      direct current cathode in the bone marrow chamber increased the number of 
      chambers containing cartilage from 50 to 80% at day 25. Mineralization also 
      occurred earlier in the chambers with direct current.
FAU - Friedenberg, Z B
AU  - Friedenberg ZB
AD  - Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, 
      Philadelphia.
FAU - Brighton, C T
AU  - Brighton CT
FAU - Michelson, J D
AU  - Michelson JD
FAU - Bednar, J
AU  - Bednar J
FAU - Schmidt, R
AU  - Schmidt R
FAU - Brockmeyer, T
AU  - Brockmeyer T
LA  - eng
GR  - AM 18033/AM/NIADDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Orthop Res
JT  - Journal of orthopaedic research : official publication of the Orthopaedic 
      Research Society
JID - 8404726
RN  - 0 (Minerals)
SB  - IM
MH  - Animals
MH  - *Bone Marrow Cells
MH  - Bone Matrix/metabolism/*physiology
MH  - Cartilage/metabolism/physiology
MH  - Cell Division
MH  - Cells, Cultured
MH  - Electric Stimulation/methods
MH  - Minerals/metabolism
MH  - Osteogenesis
OID - NASA: 89068259
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1002/jor.1100070104 [doi]
PST - ppublish
SO  - J Orthop Res. 1989;7(1):22-7. doi: 10.1002/jor.1100070104.