PMID- 29089129
OWN - NLM
STAT- MEDLINE
DCOM- 20180503
LR  - 20180503
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 618
DP  - 2018 Mar 15
TI  - Effects of prenatal di(2-ethylhexyl) phthalate exposure on childhood allergies 
      and infectious diseases: The Hokkaido Study on Environment and Children's Health.
PG  - 1408-1415
LID - S0048-9697(17)32621-9 [pii]
LID - 10.1016/j.scitotenv.2017.09.270 [doi]
AB  - Phthalates are widely used in consumer products, and experimental studies suggest 
      that exposure to phthalates increase the risk of allergies. However, 
      epidemiologic evidence on the associations between prenatal phthalate exposure 
      and allergies/infectious diseases and cord blood immunoglobulin E (IgE) levels is 
      limited. This study aimed to evaluate the associations between maternal 
      mono(2-ethylhexyl) phthalate (MEHP) levels and cord blood IgE levels at birth 
      (n=127), as well as the risk of allergies/infectious diseases in participants up 
      to 7years of age; the participants were 1.5 (n=248), 3.5 (n=222), 7 (n=184) years 
      of age. Maternal blood MEHP level in the second trimester was measured using gas 
      chromatography-mass spectrometry. Participant characteristics were obtained from 
      the medical birth records and self-administered questionnaires during pregnancy 
      and after delivery. Wheeze and eczema were defined according to the Japanese 
      version of the International Study of Asthma and Allergies in Childhood and the 
      American Thoracic Society-Division of Lung Diseases questionnaire, respectively. 
      Infectious diseases were defined using questionnaires for each specified age. To 
      evaluate the associations between maternal MEHP and allergies or infectious 
      diseases, we used logistic regression analysis and generalized estimating 
      equations analysis. Maternal MEHP levels were negatively associated with cord 
      blood IgE levels and increased risks of allergies and infectious diseases up to 
      7years of age. This is the first study to investigate the effects of prenatal 
      MEHP exposure on IgE levels at birth and allergies/infectious diseases up to 
      7years of age. Further epidemiological studies should focus on other phthalate 
      metabolites and their health effects on larger populations.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Ait Bamai, Yu
AU  - Ait Bamai Y
AD  - Center for Environmental and Health Sciences, Hokkaido University, North 12, West 
      7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Miyashita, Chihiro
AU  - Miyashita C
AD  - Center for Environmental and Health Sciences, Hokkaido University, North 12, West 
      7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Araki, Atsuko
AU  - Araki A
AD  - Center for Environmental and Health Sciences, Hokkaido University, North 12, West 
      7, Kita-ku, Sapporo 060-0812, Japan.
FAU - Nakajima, Tamie
AU  - Nakajima T
AD  - College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, 
      Kasugai 487-8501, Japan.
FAU - Sasaki, Seiko
AU  - Sasaki S
AD  - Department of Public Health, Graduate School of Medicine, Hokkaido University, 
      Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan.
FAU - Kishi, Reiko
AU  - Kishi R
AD  - Center for Environmental and Health Sciences, Hokkaido University, North 12, West 
      7, Kita-ku, Sapporo 060-0812, Japan. Electronic address: 
      rkishi@med.hokudai.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20171028
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Environmental Pollutants)
RN  - 0 (Phthalic Acids)
RN  - 6O7F7IX66E (phthalic acid)
SB  - IM
MH  - Child
MH  - Communicable Diseases/*epidemiology
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*epidemiology
MH  - Japan
MH  - Male
MH  - Maternal Exposure/*statistics & numerical data
MH  - Phthalic Acids/*blood
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*epidemiology
OTO - NOTNLM
OT  - Allergies
OT  - Children
OT  - Immunoglobulin E
OT  - Infectious diseases
OT  - Prenatal exposure
OT  - di(2-Ethylhexyl) phthalate
EDAT- 2017/11/02 06:00
MHDA- 2018/05/04 06:00
CRDT- 2017/11/02 06:00
PHST- 2017/05/12 00:00 [received]
PHST- 2017/09/25 00:00 [revised]
PHST- 2017/09/25 00:00 [accepted]
PHST- 2017/11/02 06:00 [pubmed]
PHST- 2018/05/04 06:00 [medline]
PHST- 2017/11/02 06:00 [entrez]
AID - S0048-9697(17)32621-9 [pii]
AID - 10.1016/j.scitotenv.2017.09.270 [doi]
PST - ppublish
SO  - Sci Total Environ. 2018 Mar 15;618:1408-1415. doi: 
      10.1016/j.scitotenv.2017.09.270. Epub 2017 Oct 28.