PMID- 29089185
OWN - NLM
STAT- MEDLINE
DCOM- 20180716
LR  - 20180905
IS  - 1878-5891 (Electronic)
IS  - 0378-5955 (Linking)
VI  - 356
DP  - 2017 Dec
TI  - Cannula-based drug delivery to the guinea pig round window causes a lasting 
      hearing loss that may be temporarily mitigated by BDNF.
PG  - 104-115
LID - S0378-5955(16)30401-4 [pii]
LID - 10.1016/j.heares.2017.10.004 [doi]
AB  - Sustained local delivery of drugs to the inner ear may be required for future 
      regenerative and protective strategies. The round window is surgically accessible 
      and a promising delivery route. To be viable, a delivery system should not cause 
      hearing loss. This study determined the effect on hearing of placing a 
      drug-delivery microcatheter on to the round window, and delivering either 
      artificial perilymph (AP) or brain-derived neurotrophic factor (BDNF) via this 
      catheter with a mini-osmotic pump. Auditory brainstem responses (ABRs) were 
      monitored for 4 months after surgery, while the AP or BDNF was administered for 
      the first month. The presence of the microcatheter - whether dry or when 
      delivering AP or BDNF for 4 weeks - was associated with an increase in ABR 
      thresholds of up to 15 dB, 16 weeks after implantation. This threshold shift was, 
      in part, delayed by the delivery of BDNF. We conclude that the chronic presence 
      of a microcatheter in the round window niche causes hearing loss, and that this 
      is exacerbated by delivery of AP, and ameliorated temporarily by delivery of 
      BDNF.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Sale, Phillip J P
AU  - Sale PJP
AD  - Otolaryngology, Department of Surgery, University of Melbourne, East Melbourne 
      3002, Australia.
FAU - Uschakov, Aaron
AU  - Uschakov A
AD  - Otolaryngology, Department of Surgery, University of Melbourne, East Melbourne 
      3002, Australia.
FAU - Saief, Tasfia
AU  - Saief T
AD  - Otolaryngology, Department of Surgery, University of Melbourne, East Melbourne 
      3002, Australia.
FAU - Rowe, David P
AU  - Rowe DP
AD  - Otolaryngology, Department of Surgery, University of Melbourne, East Melbourne 
      3002, Australia.
FAU - Abbott, Carla J
AU  - Abbott CJ
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East 
      Melbourne 3002, Australia; Ophthalmology, Department of Surgery, University of 
      Melbourne, Parkville 3010, Australia.
FAU - Luu, Chi D
AU  - Luu CD
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East 
      Melbourne 3002, Australia; Ophthalmology, Department of Surgery, University of 
      Melbourne, Parkville 3010, Australia.
FAU - Hampson, Amy J
AU  - Hampson AJ
AD  - Otolaryngology, Department of Surgery, University of Melbourne, East Melbourne 
      3002, Australia.
FAU - O'Leary, Stephen J
AU  - O'Leary SJ
AD  - Otolaryngology, Department of Surgery, University of Melbourne, East Melbourne 
      3002, Australia. Electronic address: sjoleary@unimelb.edu.au.
FAU - Sly, David J
AU  - Sly DJ
AD  - Otolaryngology, Department of Surgery, University of Melbourne, East Melbourne 
      3002, Australia; Department of Health and Medical Sciences, Swinburne University 
      of Technology, Hawthorn 3122, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171028
PL  - Netherlands
TA  - Hear Res
JT  - Hearing research
JID - 7900445
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Acoustic Stimulation
MH  - Animals
MH  - Audiometry, Pure-Tone
MH  - Auditory Fatigue/drug effects
MH  - Brain-Derived Neurotrophic Factor/*administration & dosage
MH  - Catheterization/*instrumentation
MH  - *Catheters, Indwelling
MH  - *Central Venous Catheters
MH  - Disease Models, Animal
MH  - Drug Delivery Systems/*instrumentation
MH  - Evoked Potentials, Auditory, Brain Stem/drug effects
MH  - Guinea Pigs
MH  - Hearing/*drug effects
MH  - Hearing Loss/diagnostic imaging/*drug therapy/etiology/physiopathology
MH  - Infusion Pumps, Implantable
MH  - Microscopy, Confocal
MH  - Perilymph/chemistry
MH  - Recovery of Function
MH  - Round Window, Ear/diagnostic imaging/*drug effects/physiopathology
MH  - Time Factors
MH  - Tomography, Optical Coherence
OTO - NOTNLM
OT  - Drug delivery
OT  - Neurotrophins
OT  - OCT
OT  - Round window
EDAT- 2017/11/02 06:00
MHDA- 2018/07/17 06:00
CRDT- 2017/11/02 06:00
PHST- 2016/10/04 00:00 [received]
PHST- 2017/09/22 00:00 [revised]
PHST- 2017/10/11 00:00 [accepted]
PHST- 2017/11/02 06:00 [pubmed]
PHST- 2018/07/17 06:00 [medline]
PHST- 2017/11/02 06:00 [entrez]
AID - S0378-5955(16)30401-4 [pii]
AID - 10.1016/j.heares.2017.10.004 [doi]
PST - ppublish
SO  - Hear Res. 2017 Dec;356:104-115. doi: 10.1016/j.heares.2017.10.004. Epub 2017 Oct 
      28.