PMID- 29089899
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 8
DP  - 2017
TI  - mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass.
PG  - 788
LID - 10.3389/fphys.2017.00788 [doi]
LID - 788
AB  - Maintenance of skeletal muscle mass is regulated by the balance between anabolic 
      and catabolic processes. Mammalian target of rapamycin (mTOR) is an 
      evolutionarily conserved serine/threonine kinase, and is known to play vital 
      roles in protein synthesis. Recent findings have continued to refine our 
      understanding of the function of mTOR in maintaining skeletal muscle mass. mTOR 
      controls the anabolic and catabolic signaling of skeletal muscle mass, resulting 
      in the modulation of muscle hypertrophy and muscle wastage. This review will 
      highlight the fundamental role of mTOR in skeletal muscle growth by summarizing 
      the phenotype of skeletal-specific mTOR deficiency. In addition, the evidence 
      that mTOR is a dual regulator of anabolism and catabolism in skeletal muscle mass 
      will be discussed. A full understanding of mTOR signaling in the maintenance of 
      skeletal muscle mass could help to develop mTOR-targeted therapeutics to prevent 
      muscle wasting.
FAU - Yoon, Mee-Sup
AU  - Yoon MS
AD  - Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, 
      South Korea.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171017
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC5650960
OTO - NOTNLM
OT  - atrophy
OT  - hypertrophy
OT  - mTOR
OT  - sarcopenia
OT  - skeletal muscle
EDAT- 2017/11/02 06:00
MHDA- 2017/11/02 06:01
PMCR- 2017/10/17
CRDT- 2017/11/02 06:00
PHST- 2017/07/20 00:00 [received]
PHST- 2017/09/26 00:00 [accepted]
PHST- 2017/11/02 06:00 [entrez]
PHST- 2017/11/02 06:00 [pubmed]
PHST- 2017/11/02 06:01 [medline]
PHST- 2017/10/17 00:00 [pmc-release]
AID - 10.3389/fphys.2017.00788 [doi]
PST - epublish
SO  - Front Physiol. 2017 Oct 17;8:788. doi: 10.3389/fphys.2017.00788. eCollection 
      2017.